Abstract
Homoeo-box genes play a central role in the regulation of embryogenesis in Drosophila melanogaster1–6. Their widespread phylogenetic distribution7–9, and the tissue and stage specificity of their expression in other organisms10–16, argue that they play a general and significant role in animal development. In D. melanogaster, all homoeo-box genes characterized to date are involved in major aspects of embryogenesis. We report here the molecular characterization of a Drosophila homoeo-box gene that has no apparent involvement in early embryogenesis. The gene appears to be rough, a gene implicated in pattern formation in the developing eye17,18. It is expressed in cells within, and posterior to, the morphogenetic furrow, the site of the primary pattern forming events in the developing retina19–22, and also in a region of the brain of the third instar larva. We have found no genetic or molecular evidence of a role for this gene in other aspects of fly development.
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References
McGinnis, W., Levine, M. S., Hafen, E., Kuroiwa, A. & Gehring, W. J. Nature 308, 428–433 (1984).
Scott, M. P. & Weiner, A. J. Proc. natn. Acad. Sci. 81, 4115–4119 (1984).
Fjosc, A., McGinnis, W. & Gehring, W. J. Nature 313, 284–289 (1985).
Doyle, H. J., Harding, K., Hoey, T. & Levine, M. Nature 323, 76–79 (1986).
Figerio, G., Burri, M., Bopp, D., Baumgartner, S. & Noll, M. Cell 47, 735–746 (1986).
Macdonald, P. M., Ingham, P. & Struhl, G. Cell 47, 721–734 (1986).
McGinnis, W., Garber, R. L., Wirz, J., Kuroiwa, A. & Gehring, W. Cell 37, 403–408 (1984).
Holland, P. W. H. & Hogan, B. L. M. Nature 321, 251–253 (1986).
McGinnis, W. Cold Spring Harb. Symp. quant. Biol. 50, 263–270 (1985).
Awgulewitsch, A., Utset, M. F., Hart, C. P., McGinnis, W. & Ruddle, F. H. Nature 320, 328–335 (1986).
Dolecki, G. J. et al. EMBO J. 5, 925–930 (1986).
Gaunt, S. J., Miller, R. J., Powell, D. J. & Duboule, D. Nature 324, 662–664 (1986).
Simeone, A. et al. Nature 320, 763–765 (1986).
Wolgemuth, D. J. et al. EMBO J. 5, 1229–1235 (1986).
Dony, C. & Gruss, P. EMBO J. 6, 2965–2979 (1987).
Toth, L. E., Slawin, K. L., Pintar, J. E. & Nguyen-Huu, M. C. Proc. natn. Acad. Sci. U.S.A. 84, 6790–6794 (1987).
Pilkington, R. W. Proc. zool. Soc. Lond. A 111, 199–222 (1941).
Meyerowitz, E. M. & Kankel, D. R. Devl Biol. 62, 112–142 (1978).
Ready, D. F., Hanson, T. E. & Benzer, S. Devl Biol. 53, 217–240 (1976).
Campos-Ortega, J. A. Curr. Topics dev. Biol. 15, 347–371 (1980).
Tomlinson, A. J. Embryol. exp. Morph. 89, 313–331 (1985).
Tomlinson, A. & Ready, D. F. Devl Biol. 120, 366–376 (1987).
Laughon, A. & Scott, M. P. Nature 310, 25–31 (1984).
Campos-Ortega, J. A., Jurgens, G. & Hofbauer, A. Wilhelm Roux Arch. dev. Biol. 186, 27–50 (1977).
Tomlinson, A. & Ready, D. F. Science 231, 400–402 (1986).
Tomlinson, A. & Ready, D. F. Devl Biol. 123, 264–275 (1987).
Banerjee, U., Renfranz, P. J., Pollock, J. A. & Benzer, S. Cell 49, 281–291 (1987).
Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55–63 (1987).
Banerjee, U., Renfranz, P. J., Hinton, D. R., Rabin, B. A. & Benzer, S. Cell 51, 151–158 (1987).
Tomlinson, A., Bowtell, D. D. L., Hafen, E. & Rubin, G. M. Cell 51, 143–150 (1987).
Zipursky, S. L., Venkatesh, T. R., Teplow, D. B. & Benzer, S. Cell 36, 15–26 (1984).
Chadwick, R. & McGinnis, W. EMBO J. 6, 779–789 (1987).
Martinez-Arias, A., Ingham, P. W., Scott, M. P. & Akam, M. E. Development 100, 673–683 (1987).
Langer-Safer, P. R., Levine, M. & Ward, D. C. Proc. natn. Acad. Sci. U.S.A. 79, 4381–4385 (1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Lewis, E. B. & Bacher, F. Drosoph. Inf. Serv. 44, 48.
Ingham, P. W. Cold Spring Harb. Symp. quant. Biol. 50, 201–208 (1985).
Akam, M. E. & Martinez-Arias, A. EMBO J. 4, 1689–1700 (1985).
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Saint, R., Kalionis, B., Lockett, T. et al. Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough. Nature 334, 151–154 (1988). https://doi.org/10.1038/334151a0
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DOI: https://doi.org/10.1038/334151a0
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