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Interaction of antibiotics with functional sites in 16S ribosomal RNA

Nature volume 327, pages 389–394 (1987)Cite this article

Abstract

Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.

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Authors and Affiliations

  1. Thimann Laboratories, University of California at Santa Cruz, Santa Cruz, California, 95064, USA

    Danesh Moazed & Harry F. Noller

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  1. Danesh Moazed
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  2. Harry F. Noller
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Moazed, D., Noller, H. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327, 389–394 (1987). https://doi.org/10.1038/327389a0

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