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Knowledge-based prediction of protein structures and the design of novel molecules

Nature volume 326, pages 347–352 (1987)Cite this article

Abstract

Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach. This depends on identification of analogies in secondary structures, motifs, domains or ligand interactions between a protein to be modelled and those of known three-dimensional structures. Such techniques are of value in prediction of receptor structures to aid the design of drugs, herbicides or pesticides, antigens in vaccine design, and novel molecules in protein engineering.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK

    T. L. Blundell, B. L. Sibanda, M. J. E. Sternberg & J. M. Thornton

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  1. T. L. Blundell
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  2. B. L. Sibanda
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  3. M. J. E. Sternberg
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  4. J. M. Thornton
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Blundell, T., Sibanda, B., Sternberg, M. et al. Knowledge-based prediction of protein structures and the design of novel molecules. Nature 326, 347–352 (1987). https://doi.org/10.1038/326347a0

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