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Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit

Nature volume 319, pages 368–374 (1986)Cite this article

Abstract

We have isolated a complementary DNA clone containing sequences homologous to those encoding the α-subunit of a mouse muscle nicotinic acetylcholine receptor. Based on the structural similarities between the encoded protein and the muscle acetylcholine receptor α-subunit, and the presence of hybridizing RNA species in the brain, we propose that this clone codes for a neural nicotinic acetylcholine receptor α-subunit.

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Authors and Affiliations

  1. Molecular Neurobiology Laboratory, Salk Institute, PO Box 85800, San Diego, California, 92138, USA

    Jim Boulter, Karen Evans, Dan Goldman, Gary Martin, Doug Treco, Steve Heinemann & Jim Patrick

Authors
  1. Jim Boulter
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  2. Karen Evans
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  3. Dan Goldman
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  4. Gary Martin
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  5. Doug Treco
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  6. Steve Heinemann
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  7. Jim Patrick
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Boulter, J., Evans, K., Goldman, D. et al. Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit. Nature 319, 368–374 (1986). https://doi.org/10.1038/319368a0

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