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Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

Nature volume 310, pages 650–655 (1984)Cite this article

Abstract

The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

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Authors and Affiliations

  1. Biogen Research Corporation, 14 Cambridge Center, Cambridge, Massachusetts, 02142, USA

    Elisabeth H. Weiss, Lynn Golden, Karen Fahrner, Andrew L. Mellor, James J. Devlin, Harm Tiddens & Richard A. Flavell

  2. Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    Elisabeth H. Weiss, Lynn Golden, Andrew L. Mellor, Hilary Bullman, Harriet Bud & Richard A. Flavell

Authors
  1. Elisabeth H. Weiss
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  2. Lynn Golden
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  3. Karen Fahrner
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  4. Andrew L. Mellor
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  5. James J. Devlin
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  6. Hilary Bullman
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  7. Harm Tiddens
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  8. Harriet Bud
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  9. Richard A. Flavell
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Weiss, E., Golden, L., Fahrner, K. et al. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature 310, 650–655 (1984). https://doi.org/10.1038/310650a0

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