Abstract
Immunoglobulin D (IgD) is co-expressed with immunoglobulin M (IgM) on the membranes of most B cells, yet its biological function has remained a mystery. Recent detailed information on the structure and transcription of the unusual IgD heavy chain (δ) gene in mouse suggests a complex genetic control A model is presented for the developmental regulation of IgM and IgD and roles suggested for the membrane and secreted forms of IgD in the immune network.
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References
Shimizu, A., Takahashi, N., Yoshita, Y. & Honjo, T. Cell 28, 499–506 (1982).
Marcu, K. B. Cell 29, 719–721 (1982).
Tonegawa, S. Nature 302, 575–581 (1983).
Cosenza, H. & Köhler, H. Proc. natn. Acad. Sci. U.S.A. 69, 2701–2705 (1972).
Eichman, K. & Rajewsky, K., Eur. J. Immun. 5, 661–666 (1975).
Van Boxel, J. A., Paul, W. E., Terry, W. D. & Green, I. J. Immun. 109, 648–651 (1972).
Vitetta, E. S. et al. J. Exp. Med. 141, 206–215.
Rowe, D. S. & Fahey, J. L. J. exp. Med. 121, 171–178 (1965).
Pernis, B., Forni, L. & Luzzati, A. L. Cold Spring Harb. Symp. quant. Biol. 41, 139–145 (1976).
Cooper, M. D., Kearney, J. F., Lydyard, P. M., Grossi, C. E. & Lawton, A. R. Cold Spring Harb. Symp. quant. Biol. 41, 139–147 (1976).
Goding, J. W., Scott, D. W. & Layton, J. E. Immun. Rev. 37, 152–186 (1977).
Vitetta, E. S. & Uhr, J. E. Eur. J. Immun. 6, 140–143 (1976).
Kearney, J. F. et al. J. exp. Med. 146, 297–301 (1977).
Layton, J. E., Johnson, G. R., Scott, D. W. & Nossal, G. J. V. Eur. J. Immun. 8 325–330 (1978).
Stern, C. & McConnell, I. Eur. J. Immun. 6, 225–227 (1979).
Goding, J. W. & Layton, J. E. J. exp. Med. 144, 852–857 (1976).
Bargellesi, A., Corte, G., Cosulich, E. E. & Ferrarini, M. Eur. J. Immun. 9, 490–492 (1979).
Finkelman, F. D., Woods, V. L., Berning, A. & Scher, I. J. Immun. 123, 1253–1259 (1979).
Parker, D. C. Immun. Rev. 52, 115–139 (1980).
Vitetta, E. S., Pure, E., Isakson, P. C., Buck, L. & Uhr, J. W. Immun. Rev. 52, 211–231 (1980).
Sieckmann, D. G., Scher, I., Asofsky, R., Mosier, D. E. & Paul, W. E. J. exp. Med. 148, 1628–1643 (1978).
Vitetta, E. S. & Uhr, J. W. Science 189, 964–969 (1975).
Scott, D. W., Layton, J. E. & Nossal, G. J. V. J. exp. Med. 146, 1473–1483 (1977).
Bourgois, A., Kitajima, K., Hunger, I. R. & Askonas, B. A. Eur. J. Immun. 7, 151–153 (1977).
Sitia, R., Abbott, J. & Hammerling, U. Eur. J. Immun. 9, 859–864 (1979).
Parker, D. C., Fothergill, J. J. & Wadsworth, D. C. J. Immun. 123, 931–941 (1979).
Isakson, P. C., Pure, E., Uhr, J. W. & Vitetta, E. S. Proc. natn. Acad. Sci. U.S.A. 78, 2507–2511 (1981).
Black, S. J. Van du Loo, W., Loken, M. R. & Herzenberg, L. A. J. exp. Med. 147, 984–996 (1980).
Herzenberg, L. A., Black, S. J., Tokuhisa, T. & Herzenberg, L. A. J exp. Med. 151, 1071–1087 (1980).
Zan-Bar, I., Strober, S. & Vitetta, E. S. J. Immun. 123, 925–930 (1979).
Coffman, R. L. & Cohn, M. J. Immun. 118, 1806–1815 (1977).
Jacobsen, E. B. et al. J. exp. Med. 154, 318–332 (1981).
Manning, D. D. J. reticuloendothel. Soc. 18, 63–86 (1975).
Cooper, M. D., Kearney, J. F., Gathings, W. E. & Lawton, A. R. Immun. Rev. 52, 29–53 (1980).
Zitron, M., Mosier, D. E. & Paul, W. E. J. exp. Med. 146, 1707–1718 (1977).
Cambier, J. C. & Vitetta, E. S. Proc. natn. Acad. Sci. U.S.A. 78, 432–435 (1978).
Tucker, P. W., Liu, C.-P., Mushinski, J. F. & Blattner, F. R. Science 209, 1353–1360 (1980).
Cheng, H.-L., Blattner, F. R., Fitzmaurice, L., Mushinski, J. F. & Tucker, P. W. Nature 296, 410–415 (1982).
Eidels, L. J. Immun. 123, 891–902 (1979).
Mescher, M. & Pollack, R. R. J. Immun. 123, 1155–1161 (1979).
Finkelman, F. D., Kessler, S. W., Mushinski, J. F. & Potter, M. J. Immun. 126, 680–687 (1981).
Early, P. et al. Cell 20, 313–319 (1980).
Kawakami, T., Takahashi, N. & Honjo, T. Nucleic Acids Res. 8, 3933–3945 (1981).
Alt, F. W. et al. Cell 20, 293–302 (1980).
Rogers, J. et al. Cell 20, 303–312 (1980).
Liu, C.-P., Tucker, P. W., Mushinski, J. F. & Blattner, F. R. Science 209, 1348–1352 (1980).
Moore, K. W. et al. Proc. natn. Acad. Sci. U.S.A. 78, 1800–1804 (1981).
Maki, R. et al. Cell 24, 353–365 (1981).
Knapp, M. R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2996–3000 (1982).
Knapp, M. R. et al. J. Immun. 123, 992–999 (1979).
Rasche, W. C. Curr. Topics Microbiol. Immun. 81, 70–76 (1978).
Knapp, M. R., Severinson-Gronowicz, E., Schroeder, J. & Strober, S. J. Immun. 123, 1000–1006 (1979).
Wabl, M. et al. Proc. natn. Acad. Sci U.S.A. 77, 6793–6796 (1980).
Nikaido, T., Yamawaki-Kataoka, Y. & Honjo, T. J. biol. Chem. 257, 7322–7329 (1982).
Richards, J. E., Gilliam, A. C., Shen, A., Tucker, P. W. & Blattner, F. R. Nature 306, 483–487 (1983).
Nikaido, T., Nakai, S. & Honjo, T. Nature 292, 845–848 (1981).
Davis, M. M., Kim, S. K. & Hood, L. Cell 22, 1–2 (1980).
Marcu, K. B., Lang, R. B., Stanton, L. W. & Harris, L. J. Nature 298, 87–89 (1982).
Mushinski, J. F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7405–7409 (1981).
Sablitzky, F., Radbruch, A. & Rajewsky, K. R. Immun. Rev. 67, 59–72 (1982).
Mather, E. L. & Perry, R. P. Nucleic Acids Res. 9, 6855–6866 (1981).
Mount, S. M. Nucleic Acids Res. 10, 459–472 (1982).
Darnell, J. E. Nature 297, 365–371 (1982).
Ziff, E. B. Nature 278, 491–499 (1980).
Nevins, J. R. Cell 28, 1–2 (1982).
Hofer, E., Hofer-Warbinek, R. & Darnell, J. E. Cell 29, 887–893 (1982).
Proudfoot, N. Nature 298, 516–517 (1982).
Proudfoot, N. J. & Brownlee, G. G. Nature 252, 359–362 (1964).
Hagenbuchle, O., Bovey, R. & Young, R. A. Cell 21, 179–187 (1980).
Nelson, K. J., Haimovich, J. & Perry, R. P. Molec. cell. Biol. 3, 1317–1332 (1983).
Defranco, A. L., Raveche, E. S., Asofsky, R. & Paul, W. E. J. exp. Med. 155, 1523–1536 (1982).
Cohen, P., Ziff, M. & Vitetta, E. S. J. Immun. 121, 973–980 (1978).
Kemp, D. J., Morahan, G., Cowman, A. F. & Harris, A. W. J. Cell Biochem. 6, 310 (1982).
Melchers, F. & Cone, R., Eur. J. Immun. 5, 382–388 (1975).
Yaoita, Y., Kumagai, Y., Okumura, K. & Honjo, T. Nature 297, 697–699 (1982).
Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).
Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).
Queen, C. & Baltimore, D. Cell 33, 741–748 (1983).
Rogers, J. & Wall, R. Proc. natn. Acad. Sci. U.S.A. 78, 7497–7501 (1982).
Yuan, D. & Tucker, P. W. J. Immun, (in the press).
Pure, E. & Vitetta, E. S. J. Immun. 125, 420–427 (1980).
Jerne, N. K. Ann. Immun. Inst. Pasteur 125C, 373–389 (1974).
Kelsoe, G., Reth, M. & Rawesky, K. Immun. Rev. 52, 75–88 (1980).
Hiernaux, J. Fedn Proc. 40, 1484–1488 (1981).
Tokuhisa, T. & Taniguchi, M. J. exp. Med. 155, 126–139 (1982).
Janeway, C. A. Jr, Sakato, N. & Eisen, H. N. Proc. natn. Acad. Sci. U.S.A. 72, 2357–2360 (1975).
Janeway, C. A. Jr & Frost, R. in Strategies of Immune Regulation (eds Sercarz, E. & Cunningham, A.) 179 (Academic, New York, 1980).
Lin, L.-C. & Putnam, F. W. Proc. natn. Acad. Sci U.S.A. 78, 504–508 (1981).
Putnam, F. W., Takahashi, N., Tetaert, D., Debuire, B. & Lin, L.-C. Proc. natn. Acad. Sci U.S.A. 78, 6168–6172 (1981).
Takahashi, N., Tetaert, D., Debuire, B., Lin, L.-C. & Putnam, F. W. Proc. natn. Acad. Sci. U.S.A. 79, 2850–2854 (1982).
Shinoda, T. N., Takahashi, T., Takayasu, T., Okuyama, T. & Shimizu, A. Proc. natn. Acad. Sci. U.S.A. 78, 785–789 (1981).
Rabbitts, T. H., Forster, A. & Milstein, C. P. Nucleic Acids Res. 9, 4509–4524 (1981).
Alcaraz, G., Bourgois, A., Moulin, A., Bozin, H. & Fourgeraeu, M. Annls Immun. Inst. Pasteur, Paris 131C, 363–388 (1980).
Sire, J., Auffray, C. & Jordan, B. R. Gene 20, 377–386 (1982).
Dildrop, R. & Beyruther, K. Nature 292, 61–63 (1981).
Poljak, R. J. CRC crit. Rev. Biochem. 5, 45–68 (1978).
Leslie, G. A. & Cuchens, M. A. Ann. N. Y. Acad. Sci. 399, 131–141 (1982).
Fitzmaurice, L. et al. Nature 296, 459–462 (1982).
Siden, E., Alt, F. W., Shinefeld, L., Sato, V. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A. 78, 1823–1827 (1981).
Alt, F. W., Rosenberg, N. E., Enea, V., Siden, E. & Baltimore, D. Molec. cell. Biol. 2, 386–400 (1982).
Kemp, D. J., Harris, A. W., Cory, S. & Adams, J. Proc. natn. Acad. Sci. U.S.A. 77, 2876–2880 (1980).
Honjo, T. et al. Cell 18, 559–568 (1979).
Rogers, J. et al. Cell 26, 19–27 (1981).
Yamawaki-Kataoka, Y., Nakai, S., Miyata, T. & Honjo, T. Proc. natn. Acad. Sci. U.S.A. 79, 2623–2627 (1982).
Tyler, B. M., Cowman, A. F., Gerondakis, S. D., Adams, J. M. & Bernard, O. Proc. natn. Acad. Sci. U.S.A. 79, 2008–2012 (1982).
Tucker, P. W., Marcu, K. B., Newell, N. N., Richards, J. E. & Blattner, F. R. Science 206, 1303–1306 (1979).
Yamawaki-Kataoka, Y., Miyata, T. & Honjo, T. Nucleic Acids Res. 9, 1365–1381 (1981).
Nishida, Y. et al. Proc. natn. Acad. Sci. U.S.A. 78, 1581–1585 (1981).
Ishida, N., Ueda, S., Hayashida, H., Miyata, T. & Honjo, T. EMBO J. 1, 1117–1123 (1982).
Tucker, P. W., Slightom, J. S. & Blattner, F. R. Proc. natn. Acad. Sci. U.S.A. 78, 7684–7688 (1981).
Word, C. J., Mushinski, J. F. & Tucker, P. W. EMBO J. 2, 887–898 (1983).
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Blattner, F., Tucker, P. The molecular biology of immunoglobulin D. Nature 307, 417–422 (1984). https://doi.org/10.1038/307417a0
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DOI: https://doi.org/10.1038/307417a0
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