Abstract
Immune response genes in the I region of the mouse major histocompatibility complex (MHC) have been divided operationally according to whether they control responses to antigens which do or do not induce active suppression in non-responder animals (IS and IR genes respectively)1,2. Studies presented here, however, show that the synthetic terpolymer poly-L-(tyrosine, glutamic acid)-poly-DL-alanine-poly-L-lysine (TGAL)3,4, commonly considered the prototype of antigens which do not induce suppression, actually serves as a potent inducer of epitope-specific suppression for antibody responses in non-responder mice.
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Herzenberg, L., Tokuhisa, T., Hayakawa, K. et al. Lack of immune response gene control for induction of epitope-specific suppression by TGAL antigen. Nature 295, 329–331 (1982). https://doi.org/10.1038/295329a0
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DOI: https://doi.org/10.1038/295329a0
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