Abstract
A number of local anaesthetics are now widely used as cardiac antiarrhythmic agents, but the cellular basis for these actions in the heart remains controversial1. One hypothesis is that agents such as lidocaine and quinidine selectively depress the fast inward current, INa. We have now tested this hypothesis using recently developed techniques for isolating and voltage clamping rat ventricular cells. Our results provide direct evidence that therapeutic doses (10–20 μM) of lidocaine or quinidine strongly inhibit INa, and give some clues about the mechanism of this inhibition.
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Lee, K., Hume, J., Giles, W. et al. Sodium current depression by lidocaine and quinidine in isolated ventricular cells. Nature 291, 325–327 (1981). https://doi.org/10.1038/291325a0
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DOI: https://doi.org/10.1038/291325a0
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