Abstract
Embryonal carcinoma (EC) cells are susceptible to infection by a variety of viruses1, but do not become resistant to infection by Semliki Forest virus2 or vesicular stomatitis virus3 (VSV) on treatment with interferon. These observations have led to the conclusion that interferon does not induce an antiviral state in EC cells2,3. We report here, however, that EC cells treated with interferon become resistant to infection by two picornaviruses and two ts mutants of VSV, whereas they remain sensitive to wild-type VSV, Sindbis and influenza virus infection. These results suggest that a partial antiviral state is induced in EC cells by interferon and that the induced antiviral protein(s) interferes with the replication of specific viruses. A significant common feature of these viruses is their replication through structures containing double-stranded RNA (dsRNA)4.
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Nilsen, T., Wood, D. & Baglioni, C. Virus-specific effects of interferon in embryonal carcinoma cells. Nature 286, 178–180 (1980). https://doi.org/10.1038/286178a0
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DOI: https://doi.org/10.1038/286178a0
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