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Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 1968–77

Nature volume 283, pages 454–457 (1980)Cite this article

Abstract

Haemagglutinin molecules from nine strains of A/Hong Kong/68 (H3N2) influenza virus, isolated between 1968 and 1977, were examined for changes in amino acid sequences. At least 18 changes, 9 of which were located precisely, occurred in the soluble tryptic peptides of the large haemagglutinin polypeptide (HA1) during this period. These peptides contained 262 residues (82% of HA1). In HA2, only two changes in 129 residues (58% of HA2) were detected. Sequential changes at a particular locus were not found; and as far as we can tell, once an amino acid changed, it did not change again in any subsequent variant examined.

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Author notes

  1. T. A. Dopheide and C. W. Ward: CSIRO, Division of Protein Chemistry, 343 Royal Parade, Parkville, Victoria 3052, Australia.

Authors and Affiliations

  1. Department of Microbiology, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT, 2601, Australia

    W. G. Laver, G. M. Air, T. A. Dopheide & C. W. Ward

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  1. W. G. Laver
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  2. G. M. Air
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  3. T. A. Dopheide
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  4. C. W. Ward
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Laver, W., Air, G., Dopheide, T. et al. Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 1968–77. Nature 283, 454–457 (1980). https://doi.org/10.1038/283454a0

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