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Identification and processing of proglucagon in pancreatic islets

Nature volume 282, pages 260–266 (1979)Cite this article

Abstract

Immunoprecipitation and tryptic peptide analysis of newly synthesised proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,000-MW protein lacking this hormonal sequence.

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Authors and Affiliations

  1. Department of Biochemistry, The University of Chicago, 920 East 58th Street, Chicago, Illinois, 60637

    C. Patzelt, H. S. Tager, R. J. Carroll & D. F. Steiner

Authors
  1. C. Patzelt
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  2. H. S. Tager
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  3. R. J. Carroll
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  4. D. F. Steiner
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Patzelt, C., Tager, H., Carroll, R. et al. Identification and processing of proglucagon in pancreatic islets. Nature 282, 260–266 (1979). https://doi.org/10.1038/282260a0

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