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A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

Nature volume 280, pages 370–375 (1979)Cite this article

Abstract

The active gene for a κ light chain is formed by a somatic recombination event that joins one of several hundred variable region genes to one of a series of recombination sites (J-segments) encoded close to the κ constant region gene. The nucleotide sequences of cloned germ line and somatically recombined genes define the precise organisation of these genetic segments and the site and nature of the recombination event that joined them. Apart from somatic recombination, no further alteration of the germ line sequence has occurred. The J-segment is of special interest as it encodes signals for both DNA and RNA splicing and provides a means of generating further immunoglobulin gene diversity.

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Authors and Affiliations

  1. Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20205

    J. G. Seidman, Edward E. Max & Philip Leder

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  1. J. G. Seidman
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  2. Edward E. Max
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  3. Philip Leder
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Seidman, J., Max, E. & Leder, P. A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature 280, 370–375 (1979). https://doi.org/10.1038/280370a0

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