Abstract
THE possible role of intracellular cyclic AMP in the control of cell division is the subject of much controversial literature (reviewed in refs 1, 2). In most such studies fibroblastic cell lines have been used, and various manipulations which raise intracellular concentration of cyclic AMP have been reported to inhibit cell proliferation1. Here we show that highly purified Schwann cells in dissociated cell cultures of newborn rat nerve, which divide infrequently in 10% serum, are stimulated to divide when exposed to cholera toxin (an irreversible activator of adenyl cyclase activity3,4), 3-isobutyl-L-methyl-xanthine (IBMX, a 3′,5′-cyclic nucleotide phosphodiesterase inhibitor5), or dibutyryl cyclic AMP, all of which would be expected to increase intracellular cyclic AMP levels.
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RAFF, M., HORNBY-SMITH, A. & BROCKES, J. Cyclic AMP as a mitogenic signal for cultured rat Schwann cells. Nature 273, 672–673 (1978). https://doi.org/10.1038/273672a0
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DOI: https://doi.org/10.1038/273672a0
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