Abstract
WE report here the first measurement of the effect of pressure on primary kinetic isotope effects of reactions in the liquid phase. We have determined rates of two reactions in solution by a sampling technique at pressures up to 2 kbar using both normal and deuterium-labelled reagents as indicated. Reaction (1) is between benzoic acid and diphenyldiazomethane (I) which has been shown to proceed by a rate-determining proton transfer1,2. Reaction (2) is between leuco crystal violet (II) and chloranil (III) in which the slow step is a hydride transfer3.
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ISAACS, N., JAVAID, K. & RANNALA, E. Pressure effects on proton tunnelling. Nature 268, 372 (1977). https://doi.org/10.1038/268372a0
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DOI: https://doi.org/10.1038/268372a0
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