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Hormone-dependent haematopoiesis in fibroblast-transformation ossicles

Nature volume 263, pages 514–515 (1976)Cite this article

Abstract

SUBCUTANEOUS transplantation of coarse powders of acid-insoluble matrix of the shafts of long bones of rat to allogeneic recipients results consistently in the formation of new bone through endochondral ossification1. Haematopoietic bone marrow develops in the newly formed ossicle in adolescent rats2,3 and this experimental model is amenable to an investigation of hormonal control of initiation of haematopoiesis. Erythropoiesis is dependent on pituitary hormones4,5 since hypophysectomy resulted in anaemia in all animal species which have been studied. Hypophysectomy caused a prompt regression of many stem-cell erythroblastic leukaemias in rat6. We now report the profound influence of hypophysectomy on de novo erythropoiesis in matrix-induced transformation ossicles.

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References

  1. Reddi, A. H., and Huggins, C. B., Proc. natn. Acad. Sci. U.S.A., 69, 1601–1605 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Reddi, A. H., and Huggins, C. B., Proc. natn. Acad. Sci. U.S.A., 72, 2212–2216 (1975).

    Article  ADS  CAS  Google Scholar 

  3. Reddi, A. H., and Anderson, W. A., J. Cell Biol., 69, 557–572 (1976).

    Article  CAS  Google Scholar 

  4. Crafts, R. C., and Meineke, H. A., Ann. N. Y. Acad. Sci., 77, 501–517 (1959).

    Article  ADS  CAS  Google Scholar 

  5. Krantz, S. B., and Jacobson, L. O., Erythropoietin and the Regulation of Erythropoiesis, 158–164 (University of Chicago, Chicago, 1970).

    Google Scholar 

  6. Huggins, C. B., and Oka, H., Cancer Res., 32, 239–242 (1972).

    CAS  PubMed  Google Scholar 

  7. Robison, R., Biochem. J., 17, 286–293 (1923).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois, 60637

    A. H. REDDI & CHARLES B. HUGGINS

Authors
  1. A. H. REDDI
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  2. CHARLES B. HUGGINS
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REDDI, A., HUGGINS, C. Hormone-dependent haematopoiesis in fibroblast-transformation ossicles. Nature 263, 514–515 (1976). https://doi.org/10.1038/263514a0

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