Abstract
GLUTAMATE-SENSITIVE receptors occur widely, both in vertebrate and invertebrate nerve and muscle membranes1,2. Information concerning the action of agonists on glutamate receptors and the kinetics of the associated ion channels may be obtained from a study of the noise which results from conductance fluctuations during drug action3–8. Analysis of voltage-clamped noise has been used in the present work to investigate the lifetime of an open channel in the presence of a steady concentration of a chemo-excitant, and to obtain an estimate of the single-channel conductance. In addition, we have examined the dependence of the channel duration on temperature and membrane potential and have compared the channel kinetics produced by different agonists and by the neurally released transmitter.
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ANDERSON, C., CULL-CANDY, S. & MILEDI, R. Glutamate and quisqualate noise in voltage-clamped locust muscle fibres. Nature 261, 151–153 (1976). https://doi.org/10.1038/261151a0
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DOI: https://doi.org/10.1038/261151a0
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