Abstract
EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1–8. Examples include T helper function in vivo and in vitro1–3, cytotoxicity mediated by T cells against virus-infected4–6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral infection6 in vivo. This requirement for H-2 compatibility has been studied in detail by measuring the cytotoxicity of T cells from donors immunised with either lymphocytic choriomeningitis (LCM) or ectromelia virus using target cells infected with the homologus virus.
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References
Kindred, B., and Shreffler, D. C., J. Immun., 109, 940–945 (1972).
Katz, D. H., Hamaoka, T., and Benacerraf, B., J. exp. Med., 137, 1405–1418 (1973)
Katz, D. H., Hamoaka, T., Dorf, M. E., and Benacerraf, B., Proc. natn. Acad Sci, U.S.A., 70, 2624–2628 (1973).
Doherty, P. C., and Zinkernagel, R. M., Transplant. Rev., 19, 89–120 (1974); J. Immun. (in the press); J. exp. Med. (in the press).
Zinkernagel, R. M., and Doherty, P. C., Nature, 248, 701–702, (1974); Scand. J. Immun., 3, 287–294 (1974); Nature, 251, 547–548 (1974).
Blanden, R. V., in Proc. in Immun., 11, 4 (edit. by Brent, L., and Holborrow, J.), 117–125 (North-Holland, Amsterdam, 1974).
Shearer, G. M., Eur. J. Immun., 4, 527–533 (1974).
Zinkernagel, R. M., Nature, 251, 230–233 (1974).
Fenner, F., McAuslan, B. R., Mims, C. A., Sambrook, J., and White, D. O., The Biology of Animal Viruses, second ed. (Academic, New York and London, 1974).
Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun., 112, 1548–1552.
Gardner, I. D., Bowern, N. A., and Blanden, R. V., Eur. J. Immun., 4, 63–67, 68–72, (1974); ibid (in the press).
Shreffler, D. C., and David, C. S., Adv. Immun. (in the press).
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BLANDEN, R., DOHERTY, P., DUNLOP, M. et al. Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex. Nature 254, 269–270 (1975). https://doi.org/10.1038/254269a0
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DOI: https://doi.org/10.1038/254269a0
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