Abstract
ONE of the characteristics of the transformed state in culture in mammalian fibroblasts transformed by polyoma virus and Simian Virus 40 (SV40) is the lowered serum requirement for cellular growth1–4. The participation of a viral gene(s) in this attribute of transformation has been known for polyoma virus5 and SV40 (refs 6 and 7). Recent experiments show that some of the other properties associated with the transformed state are also under the control of the same viral gene(s)6–11. The ts-a gene of polyoma virus controls the initiation of stable transformation in the hamster BHK 21 cell line12, although it is usually accepted that the function of this gene is not required for the maintenance of the transformed state12–14. I report here the temperature-sensitive growth in low serum medium of some of the rat cell lines transformed by the ts-a mutant of polyoma virus, and suggest that this viral gene controls at least one aspect of the maintenance of transformed state in certain transformed cells.
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KIMURA, G. Temperature-sensitive growth of cells transformed by ts-a mutant of polyoma virus. Nature 253, 639–641 (1975). https://doi.org/10.1038/253639b0
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DOI: https://doi.org/10.1038/253639b0
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