Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Three abundance classes in HeLa cell messenger RNA

Nature volume 250, pages 199–204 (1974)Cite this article

Abstract

Approximately 35,000 different poly(A)-containing RNA sequences are present in HeLa cell cytoplasm. The sequences are grouped in three distinct abundance classes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Darnell, J. E., Wall, R., and Tushinski, R. J., Proc. natn. Acad. Sci. U.S.A., 68, 1321–1325 (1971).

    Article  ADS  CAS  Google Scholar 

  2. Lee, S. Y., Mendecki, J., and Brawerman, G., Proc. natn. Acad. Sci. U.S.A., 68, 1331–1335 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Edmonds, M., Vaughan, M. H., and Nakazato, H., Proc. natn. Acad. Sci. U.S.A., 68, 1336–1340 (1971).

    Article  ADS  CAS  Google Scholar 

  4. Aviv, H., and Leder, P., Proc. natn. Acad. Sci., U.S.A., 69, 1408–1412 (1972).

    Article  ADS  CAS  Google Scholar 

  5. kates, J., Cold Spring Harb. Symp. quant. Biol., 35, 743–752 (1970).

    Article  CAS  Google Scholar 

  6. Britten, R. J., and Kohne, D. E., Science, 161, 529–540 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Hahn, W. E., and Laird, C. D., Science, 173, 158–161 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Davidson, E. H., and Hough, B. R., J. molec. Biol., 56, 491–506 (1971).

    Article  CAS  PubMed  Google Scholar 

  9. Brown, I. R., and Church, R. B., Biochem. biophys. Res. Commun., 42, 850–856 (1971).

    Article  CAS  PubMed  Google Scholar 

  10. Grouse, L., Chilton, M. D., and McCarthy, B. J., Biochemistry, 11, 798–805 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. Gelderman, A. H., Rake, A. V., and Britten, R. J., Proc. natn. Acad. Sci. U.S.A., 68, 172–176 (1971).

    Article  ADS  CAS  Google Scholar 

  12. Kohne, D. E., Biophys. J., 8, 1104–1121 (1968).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ross, J., Aviv, H., Scolnick, E., and Leder, P., Proc. natn. Acad. Sci. U.S.A., 69, 264–268 (1972).

    Article  ADS  CAS  Google Scholar 

  14. Verma, I. M., Temple, G. F., Fan, H., and Baltimore, D., Nature new Biol., 235, 163–167 (1972).

    Article  CAS  PubMed  Google Scholar 

  15. Kacian, D. L., Spiegelman, S., Bank, A., Terada, M., Metafora, S., Dow, L., and Marks, P. A., Nature new Biol., 235, 167–169 (1972).

    Article  CAS  Google Scholar 

  16. Laird, C. D., and McCarthy, B. J., Genetics, 60, 303–312 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Bishop, J. O., Biochem. J., 113, 805–811 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Greenberg, J. R., and Perry, R. P., J. molec. Biol., 72, 91–98 (1972).

    Article  CAS  PubMed  Google Scholar 

  19. Adesnik, M., Salditt, M., Thomas, W., and Darnell, J. E., J. molec. Biol., 71, 21–30 (1972).

    Article  CAS  PubMed  Google Scholar 

  20. Gillespie, D., Marshall, S., and Gallo, R. P., Nature new Biol., 236, 227–231 (1972).

    Article  CAS  Google Scholar 

  21. Bishop, J. O., Rosbash, M., and Evans, D., J. molec. Biol., 85, 75–86 (1974).

    Article  CAS  PubMed  Google Scholar 

  22. Sheiness, D., and Darnell, J. E., Nature new Biol., 241, 265–268 (1973).

    Article  CAS  PubMed  Google Scholar 

  23. Gierer, A., Z. Naturforsch., 13, 788–793 (1958).

    Article  Google Scholar 

  24. Spirin, A., Prog. Nucl. Acid Res., 1, 301–332 (1963).

    Article  CAS  Google Scholar 

  25. Penman, S., J. molec. Biol., 17, 117–128 (1966).

    Article  CAS  PubMed  Google Scholar 

  26. Spradling, A., Penman, S., Campo, M. S., and Bishop, J. O., Cell (in the press).

  27. Parish, J. H., and Kirby, K. S., Biochim. biophys. Acta, 129, 554–562 (1966).

    Article  CAS  PubMed  Google Scholar 

  28. Bishop, J. O., and Rosbash, M., Nature new Biol., 241, 204–207 (1973).

    Article  CAS  PubMed  Google Scholar 

  29. Kacian, D. L., Watson, K. F., Burny, A., and Spiegelman, S., Biochim. biophys. Acta, 246, 365–373 (1971).

    Article  CAS  PubMed  Google Scholar 

  30. Bishop, J. O., and Pemberton, R., in Biochemistry of Cell Differentiation (edit. by Monroy, A., and Tsanev, R.), 23–39 (Academic Press, London, 1972).

    Google Scholar 

  31. Bishop, J. O., Biochem. J., 126, 171–185 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Sutton, W. D., Biochim. biophys. Acta, 240, 522–531 (1971).

    Article  CAS  PubMed  Google Scholar 

  33. Bishop, J. O., Acta endocr., suppl. 161, 247–276 (1972).

    Article  Google Scholar 

  34. Gaskill, P., and Kabat, D., Proc. natn. Acad. Sci. U.S.A., 68, 72–75 (1971).

    Article  ADS  CAS  Google Scholar 

  35. Gould, H. J., and Hamlyn, P. H., FEES Lett., 30, 301–304 (1973).

    Article  CAS  Google Scholar 

  36. Miyazawa, Y., and Thomas, C. A., J. molec. Biol., 11, 223–237 (1965).

    Article  CAS  PubMed  Google Scholar 

  37. Grady, L. J., and Campbell, W. P., Nature new Biol., 243, 195–198 (1973).

    Article  CAS  PubMed  Google Scholar 

  38. Scherrer, K., and Marcaud, L., Bull. Soc. chim. Biol., 47, 1697–1713 (1965).

    CAS  Google Scholar 

  39. Demerec, M., Cold Spring Harb. Symp. quant. Biol., 2, 110–115 (1934).

    Article  Google Scholar 

  40. Herskowitz, I. H., Am. Nat., 84, 255–260 (1950).

    Article  Google Scholar 

  41. Judd, B. H., Shen, M. W., and Kaufman, T. C., Genetics, 71, 139–156 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Ohta, T., and Kimura, M., Nature, 233, 118–119 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  43. Weinberg, E. S., Birnstiel, M. L., Purdom, I. R., and Williamson, R., Nature, 240, 225–228 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  44. McCarthy, B. J., and Farquhar, M. N., Brookhaven Symp. Biol., 23, 1–17 (1972).

    CAS  PubMed  Google Scholar 

  45. Singer, R. H., and Penman, S., J. molec. Biol., 78, 321–334 (1973).

    Article  CAS  PubMed  Google Scholar 

  46. Greenberg, J., Nature, 240, 102–104 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN, UK

    J. O. Bishop, J. G. Morton, M. Rosbash & Melville Richardson

Authors
  1. J. O. Bishop
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. G. Morton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Rosbash
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Melville Richardson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bishop, J., Morton, J., Rosbash, M. et al. Three abundance classes in HeLa cell messenger RNA. Nature 250, 199–204 (1974). https://doi.org/10.1038/250199a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/250199a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing