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Production of antibodies to tetrahydrocannabinol as the basis for its radioimmunoassay

Abstract

TETRAHYDROCANNABINOL (THC) is the main pharmacologically active constituent of cannabis. A sensitive method for its measurement in plasma would be expected to have important clinical, experimental, and forensic uses. Brief descriptions of the production of antibodies to THC have appeared in the past1–3. In one case2, the antibodies were used to bind THC and its derivatives on a quantitative basis involving measurement of the inhibition of antibody fluorescence quenching or enhancement of hapten fluorescence when bound to antibody.

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TEALE, J., FORMAN, E., KING, L. et al. Production of antibodies to tetrahydrocannabinol as the basis for its radioimmunoassay. Nature 249, 154–155 (1974). https://doi.org/10.1038/249154a0

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