Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Effects of Lysozyme on Normal and Transformed Mammalian Cells

Nature volume 243, pages 331–335 (1973)Cite this article

Abstract

Homologous mammalian lysozymes have specific effects on the in vitro growth patterns and morphology of normal and transformed mammalian cells, apparently due to effects on constituent membranes. Lysozyme may be important in the surveillance of membranes and may be a mediator of the antitumour functions of macrophages.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Fleming, A., Proc. Roy. Soc., B, 93, 306 (1922).

    Article  ADS  CAS  Google Scholar 

  2. Imoto, T., Johnson, L. N., North, A. C. T., Phillips, D. C., and Rupley, J. A., in The Enzymes, third edit. (edit. by Boyer, P. D.) (Academic Press, New York, 1972).

    Google Scholar 

  3. Osserman, E. F., and Lawlor, D. P., J. Exp. Med., 124, 921 (1966).

    Article  CAS  Google Scholar 

  4. Rosenthal, D. S., and Moloney, W. C., Proc. Soc. Exp. Biol. Med., 126, 682 (1967).

    Article  CAS  Google Scholar 

  5. Rytömaa, T., In Vitro, 4, 47 (1969).

    Article  Google Scholar 

  6. Borek, C., Proc. US Nat. Acad. Sci., 69, 956 (1972).

    Article  ADS  CAS  Google Scholar 

  7. Katchalsky, A., Biophys. J., 4, 9 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Ambrose, E. J., in The Biology of Cancer (edit. by Ambrose, E. J., and Roe, F. J. C.), 65 (Van Nostrand, London, 1966).

    Google Scholar 

  9. Moroson, H., Cancer Res., 31, 373 (1971).

    CAS  PubMed  Google Scholar 

  10. Weiss, L., and Zeigel, R., J. Cell. Physiol., 77, 179 (1971).

    Article  CAS  Google Scholar 

  11. Weiss, L., Zeigel, R., Jung, O. S., and Bross, I. D. J., Exp. Cell Res., 70, 57 (1972).

    Article  CAS  Google Scholar 

  12. Black, M. M., Kerpe, S., and Speer, F. D., Amer. J. Pathol., 29, 505 (1953).

    CAS  Google Scholar 

  13. Hamlin, I. M. E., Brit. J. Cancer, 22, 383 (1968).

    Article  CAS  Google Scholar 

  14. Silverberg, S. G., Chitale, A. R., Hind, A. D., Frazier, A. B., and Levitt, S. H., Cancer, 26, 1177 (1970).

    Article  CAS  Google Scholar 

  15. Role du Système Reticulo-Endothelial dans l'Immunité Anti-Bactérienne et Anti-Tumorale (edit. by Halpern, B. N.), No. 115 (Editions du Centre National de la Recherche Scientifique, Paris, 1953).

  16. Thomas, L., in Cellular and Humoral Aspects of the Hypersensitive States (edit. by Lawrence, H. S.), 529 (Hoeber-Harper, New York, 1959).

    Google Scholar 

  17. Aoki, T., Teller, M. N., and Robitaille, M.-L., J. Nat. Cancer Inst., 34, 255 (1965).

    Article  CAS  Google Scholar 

  18. Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., and Stockart, E., Cancer Res., 21, 1281 (1961).

    CAS  PubMed  Google Scholar 

  19. Old, L. J., Clarke, D. A., Benacerraf, B., and Goldsmith, M., Ann. NY Acad. Sci., 88, 264 (1960).

    Article  ADS  CAS  Google Scholar 

  20. Old, L. J., Clarke, D. A., and Benacerraf, B., Nature, 184, 291 (1959).

    Article  ADS  Google Scholar 

  21. Weiss, D. W., Bonhag, R. S., and Leslie, P., J. Exp. Med., 124, 1039 (1966).

    Article  CAS  Google Scholar 

  22. Mathé, G., Schwarzenberg, L., Amiel, J. L., et al., Cancer Res., 27, 2542 (1967).

    PubMed  Google Scholar 

  23. Mathé, G., Pouillart, P., and Lapeyraque, F., Brit. J. Cancer, 23, 814 (1969).

    Article  Google Scholar 

  24. Mathé, G., Amiel, J. L., Schwarzenberg, L., et al., Lancet, i, 697 (1969).

    Article  Google Scholar 

  25. Bluming, A. Z., Vogel, C. L., Ziegler, J. L., Mody, N., and Kamya, G., Ann. Intern. Med., 76, 405 (1972).

    Article  CAS  Google Scholar 

  26. Zbar, B., and Tanaka, T., Science, 172, 271 (1971).

    Article  ADS  CAS  Google Scholar 

  27. Myrvik, Q. N., Leake, E. S., and Fariso, B., J. Immunol., 86, 133 (1961).

    CAS  PubMed  Google Scholar 

  28. Conn, Z. A., and Wiener, R., J. Exp. Med., 118, 991 (1963).

    Article  Google Scholar 

  29. Myrvik, Q. N., Leake, E. S., and Oshima, S., J. Immunol., 89, 745 (1962).

    CAS  PubMed  Google Scholar 

  30. Carson, M. E., and Dannenberg, jun., A. M., J. Immunol., 94, 99 (1965).

    CAS  PubMed  Google Scholar 

  31. Nihoul, E., Massart, L., and Van Heel, G., Arch. Intern. Pharmacodynamie, 88, 123 (1951).

    CAS  Google Scholar 

  32. Kerby, G. P., and Eadie, G. S., Proc. Soc. Exp. Biol. Med., 83, 111 (1953).

    Article  CAS  Google Scholar 

  33. Martz, E., and Benacerraf, B., Fed. Proc., 31, 786 (1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Institute of Cancer Research, Columbia University,

    E. F. OSSERMAN, M. KLOCKARS, J. HALPER & R. E. FISCHEL

  2. Department of Medicine, College of Physicians and Surgeons, 99 Fort Washington Avenue, New York City, New York, 10032

    E. F. OSSERMAN, M. KLOCKARS, J. HALPER & R. E. FISCHEL

Authors
  1. E. F. OSSERMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. KLOCKARS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. HALPER
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. E. FISCHEL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

OSSERMAN, E., KLOCKARS, M., HALPER, J. et al. Effects of Lysozyme on Normal and Transformed Mammalian Cells. Nature 243, 331–335 (1973). https://doi.org/10.1038/243331a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/243331a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing