Abstract
ELECTROENCEPHALOGRAPHIC studies of sleep suggest that the magnitude of sleep disturbances in depressed and schizophrenic subjects varies with the degree of psychic turmoil1–6. Psychoendocrine studies of psychiatric patients have suggested that adrenal cortical steroid excretion is elevated with subjective distress7–13. Some endocrine studies have shown that nocturnal secretion of adrenal cortical steroids is elevated at least part of the time in psychiatric patients14–17. We have undertaken to determine the effect of a glucocorticoid on normal human sleep.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hawkins, D. R., Mendels, J., Scott, J., Bensch, G., and Teachery, W., Psychosom. Med., 29, 329 (1967).
Mendels, J., and Hawkins, D. R., in Science and Psychoanalysis, 18, 29 (Grune and Stratton, New York, 1970).
Snyder, F., in Computers and Electronic Devices in Psychiatry (edit. by Kline, N. S., and Laska, E.), 272 (Grune and Stratton, New York, 1968).
Snyder, F., in Recent Advances in the Psychobiology of the Depressive Illnesses, sponsored by Division of Extramural Research Programs, NIMH, Chevy Chase, Maryland (in the press).
Lairy, G. C., Barte, A., Golsteinus, L., and Ridjanovic, S., in Le Sommeil de Nuit Normal et Pathologique Etudes Electroencephalographiques (edit. by Jouvet, M.), 354 (Masson, Paris, 1965).
Kupfer, D. J., Wyatt, R. J., Scott, J., and Snyder, J., Amer. J. Psychiat., 126, 1213 (1970).
Bunney, W. E., Mason, J. F., and Hamburg, D. A., Psychosom. Med., 27, 299 (1965).
Bunney, W. E., Mason, J. W., Roatch, J. R., and Hamburg, D. A., Amer. J. Psychiat., 122, 72 (1965).
Sachar, E., Mason, J. W., Kolmer, H. S., and Artiss, K. L., Psychosom. Med., 25, 510 (1963).
Sachar, E. J., Hillman, L., Fukushima, D. K., and Gallagher, T. F., Arch. Gen. Psychiat., 23, 289 (1970).
Sachar, E. J., Kanter, S. S., Birie, D., Engle, R., and Mehlman, R., Amer. J. Psychiat., 125, 1067 (1970).
Rubin, R. J., and Mandell, A. J., Amer. J. Psychiat., 123, 387 (1967).
Mason, J. W., Psychosom. Med., 30, 576 (1968).
Bridges, P. K., and Jones, M. J., Brit. J. Psychiat., 112, 1257 (1966).
Doig, R. J., Mummey, R. V., Wills, M. R., and Elhes, A., Brit. J. Psychiat., 112, 1263 (1966).
McClure, D. J., J. Psychosom. Res., 10, 189 (1966).
Roffwarg, H. R., Sachar, E., Finkelstein, J., Curti, J., Ellman, S., Krean, J., Fishman, R., Gallagher, F. T., and Hellman, L., Psychophysiology, 7, 323 (1970).
Jacobson, M. E., Postgraduate Med., 49, 181 (1971).
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects (edit. by Rechtschaffen, A., and Kales, A.) (US Government Printing Office, Washington DC, 1968).
Winer, B. J., Statistical Principles in Experimental Design (McGraw-Hill, New York, 1962).
Siegel, S., Nonparametric Statistics (McGraw-Hill, New York, 1956).
Kawakami, M., Negoro, H., and Teresawa, E., Jap. J. Physiol., 15, 1 (1965).
Cohen, H. Shane, M. D., and Dement, W. C., Biol. Psychiat., 2, 401 (1970).
Kales, A., Beall, G. N., Bajor, G. F., Jackson, A., and Kales, J. R., J. Allergy, 41, 64 (1968).
Jouvet, M., Science, 163, 32 (1969).
Wyatt, R. J., Biol. Psychiat. (in the press).
Azmitia, E. C., and McEwen, B. S., Science, 169, 201 (1970).
Maas, J. W., and Mednieks, M., Science, 171, 178 (1971).
Green, A. R., and Curzon, G., Nature, 220, 1095 (1968).
Woodbury, D. M., Pharm. Rev., 10, 275 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILLIN, J., JACOBS, L., FRAM, D. et al. Acute Effect of a Glucocorticoid on Normal Human Sleep. Nature 237, 398–399 (1972). https://doi.org/10.1038/237398a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/237398a0
This article is cited by
-
Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework
Neuropsychopharmacology (2020)
-
Sleep Disturbances in the Elderly Patient with Inflammatory Bowel Disease
Current Treatment Options in Gastroenterology (2019)
-
The role of sleep in pemphigus: a review of mechanisms and perspectives
Archives of Dermatological Research (2017)
-
Acute Cortisol Administration Promotes Sleep Intensity in Man
Neuropsychopharmacology (2004)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
