Abstract
SEVERAL studies have shown that scopolamine hydrobromide, a peripheral cholinergic blocking agent1, increases responding in situations which require response suppression2,3. Other studies4 have demonstrated similar behavioural effects when cholinergic function was modified by anticholinesterases. This disruption has been attributed to either impairment of sensory input2 or response disinhibition5. These hypotheses were tested by using a form of analysis based on the theory of signal detectability (TSD), which originated in work on electronic communication systems and has been extended to sensory psychology6. It has been particularly useful in psychophysics because it yields independent estimates of a subject's sensitivity to stimuli and his response bias.
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WARBURTON, D., BROWN, K. Attenuation of Stimulus Sensitivity induced by Scopolamine. Nature 230, 126–127 (1971). https://doi.org/10.1038/230126a0
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DOI: https://doi.org/10.1038/230126a0
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