Abstract
A DNA polymerase that can copy RNA–RNA and RNA–DNA synthetic templates has been found in normal mouse and normal human cells. Partially purified polymerases from both sources have properties that are similar to those of the mouse leukaemia virus enzyme.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Baltimore, D., Nature, 226, 1209 (1970).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Mizutani, S., Boettiger, D., and Temin, H. M., Nature, 228, 424 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).
Scolnick, E., Rands, E., Aaronson, S. A., and Todaro, G. J., Proc. US Nat. Acad. Sci., 67, 1789 (1970).
Lin, F. H., and Thormar, H., J. Virol., 6, 702 (1970).
Parks, W., Scolnick, E., Todaro, G. J., and Aaronson, S. A., Nature (in the press).
Todaro, G. J., and Aaronson, S. A., Virology, 38, 174 (1969).
Gallo, R. C., Yang, S. S., and Ting, R. C., Nature, 288, 927 (1970).
Gurgo, C., Ray, R. K., Thiry, L., and Green, M., Nature (in the press).
Lee-Huang, S., and Cavalieri, L. F., Proc. US Nat. Acad. Sci., 50, 1116 (1963).
Cavalieri, L. F., and Carroll, E., Biochem. Biophys. Res. Commun., 41, 1055 (1970).
Temin, H. M., Persp. Biol. Med. (in the press).
Gerwin, B., Todaro, G. J., Zeve, V., Scolnick, E., and Aaronson, S. A., Nature, 228, 435 (1970).
Schlom, J., Burny, A., Harter, D., and Spiegelman, S., Proc. US Nat. Acad. Sci. (in the press).
Temin, H. M., in Biology of Large RNA Viruses (edit. by Barry, R. and Mahy, B.) (Academic Press, New York, 1970).
Bader, J. P., and Bader, A. V., Proc. US Nat. Acad. Sci., 67, 843 (1970).
Kondo, M., Gallerani, R., and Weissman, C., Nature, 228, 525 (1970).
Kamen, R., Nature, 228, 527 (1970).
Aaronson, S. A., Hartley, J. W., and Todaro, G. J., Proc. US Nat. Acad. Sci., 64, 87 (1969).
Klement, V., Rowe, W. P., Hartley, J. W., and Pugh, W. E., Proc. US Nat. Acad. Sci., 63, 753 (1969).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. S., J. Biol. Chem., 193, 265 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCOLNICK, E., AARONSON, S., TODARO, G. et al. RNA Dependent DNA Polymerase Activity in Mammalian Cells. Nature 229, 318–321 (1971). https://doi.org/10.1038/229318a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/229318a0
This article is cited by
-
What history tells us XXXVI. Reverse transcriptase and Lamarckian scenarios of evolution
Journal of Biosciences (2015)
-
Retroviral properties inherent to viral erythrocytic infection in sea bass
Archives of Virology (1995)
-
The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology
Cancer Chemotherapy and Pharmacology (1990)
-
RNA-dependent DNA polymerase (reverse transcriptase)
Blut (1977)
-
Eine neue Instruktionstheorie
Infection (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.