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RNA Dependent DNA Polymerase Activity in Mammalian Cells

Abstract

A DNA polymerase that can copy RNA–RNA and RNA–DNA synthetic templates has been found in normal mouse and normal human cells. Partially purified polymerases from both sources have properties that are similar to those of the mouse leukaemia virus enzyme.

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References

  1. Baltimore, D., Nature, 226, 1209 (1970).

    Article  ADS  CAS  Google Scholar 

  2. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Mizutani, S., Boettiger, D., and Temin, H. M., Nature, 228, 424 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Scolnick, E., Rands, E., Aaronson, S. A., and Todaro, G. J., Proc. US Nat. Acad. Sci., 67, 1789 (1970).

    Article  ADS  CAS  Google Scholar 

  6. Lin, F. H., and Thormar, H., J. Virol., 6, 702 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Parks, W., Scolnick, E., Todaro, G. J., and Aaronson, S. A., Nature (in the press).

  8. Todaro, G. J., and Aaronson, S. A., Virology, 38, 174 (1969).

    Article  CAS  Google Scholar 

  9. Gallo, R. C., Yang, S. S., and Ting, R. C., Nature, 288, 927 (1970).

    Article  Google Scholar 

  10. Gurgo, C., Ray, R. K., Thiry, L., and Green, M., Nature (in the press).

  11. Lee-Huang, S., and Cavalieri, L. F., Proc. US Nat. Acad. Sci., 50, 1116 (1963).

    Article  ADS  CAS  Google Scholar 

  12. Cavalieri, L. F., and Carroll, E., Biochem. Biophys. Res. Commun., 41, 1055 (1970).

    Article  CAS  Google Scholar 

  13. Temin, H. M., Persp. Biol. Med. (in the press).

  14. Gerwin, B., Todaro, G. J., Zeve, V., Scolnick, E., and Aaronson, S. A., Nature, 228, 435 (1970).

    Article  ADS  CAS  Google Scholar 

  15. Schlom, J., Burny, A., Harter, D., and Spiegelman, S., Proc. US Nat. Acad. Sci. (in the press).

  16. Temin, H. M., in Biology of Large RNA Viruses (edit. by Barry, R. and Mahy, B.) (Academic Press, New York, 1970).

    Google Scholar 

  17. Bader, J. P., and Bader, A. V., Proc. US Nat. Acad. Sci., 67, 843 (1970).

    Article  ADS  CAS  Google Scholar 

  18. Kondo, M., Gallerani, R., and Weissman, C., Nature, 228, 525 (1970).

    Article  ADS  CAS  Google Scholar 

  19. Kamen, R., Nature, 228, 527 (1970).

    Article  ADS  CAS  Google Scholar 

  20. Aaronson, S. A., Hartley, J. W., and Todaro, G. J., Proc. US Nat. Acad. Sci., 64, 87 (1969).

    Article  ADS  CAS  Google Scholar 

  21. Klement, V., Rowe, W. P., Hartley, J. W., and Pugh, W. E., Proc. US Nat. Acad. Sci., 63, 753 (1969).

    Article  ADS  CAS  Google Scholar 

  22. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. S., J. Biol. Chem., 193, 265 (1951).

    CAS  Google Scholar 

Download references

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SCOLNICK, E., AARONSON, S., TODARO, G. et al. RNA Dependent DNA Polymerase Activity in Mammalian Cells. Nature 229, 318–321 (1971). https://doi.org/10.1038/229318a0

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