Abstract
RIFAMPICIN inhibits the replication of poxvirus1,2; experiments with other rifamycin derivatives suggested that the hydrazone side-chain of rifampicin was essential for its antiviral activity3. We describe here the action of the characteristic component of this side-chain, l-methyl-4-aminopiperazine, and compare it with that of the other analogue of rifampicin, 3-formylrifamycin SV (FSV), and another compound, l-methyl-4-benzylidenaminopiperazine, which contains the hydrazone side-chain but not the rifamycin moiety.
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References
Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).
Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).
Ben-Ishai, Z., Heller, E., Goldblum, N., and Becker, Y., Nature, 224, 29 (1969).
Bach, M. K., and Johnson, H. G., Biochemistry, 6, 1916 (1967).
Kates, J., Dahl, R., and Mielke, M., J. Virol., 2, 894 (1968).
McAuslan, B. R., Biochem. Biophys. Res. Commun., 37, 289 (1969).
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THIRY, L., LANCINI, G. Inhibition of Vaccinia Virus Growth by 1-Methyl-4-aminopiperazine. Nature 227, 1048–1050 (1970). https://doi.org/10.1038/2271048a0
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DOI: https://doi.org/10.1038/2271048a0
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