Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Structure of Rauscher Mouse Leukaemia Virus RNA

Nature volume 220, pages 396–399 (1968)Cite this article

Abstract

RNA tumour viruses are divided on the basis of their biological and serological properties into three major groups: avian leukosis sarcoma, mouse leukaemia sarcoma and mouse mammary tumour1. Common features in electron microscopic appearance2–6, chemical composition7 and the presence of a group-specific antigen common to all members of the respective groups7, suggest that all the viruses may have similar structure. Addition of inhibitors of DNA-dependent RNA synthesis to infected cultures blocks virus production for members of all three groups (refs. 8–10 and unpublished results of R. C. Cardiff and P. B. Blair), so it is also probable that they have some characteristics of replication in common. Single-stranded RNA has been isolated from several of these viruses by the SDS-phenol method11–15. In each case density gradient sedimentation of the RNA yielded a fast-sedimenting component with sedimentation coefficient (Sw) of 60S-75S which was identified as the intact viral UNA, plus a 4S component which was thought to be degraded viral or cellular RNA.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Suggestions for the Classification of Oncogenic RNA Viruses. Contributions from the Stern Symposium on Perspectives in Virology, New York, February 9, 1966. J. Nat. Cancer Inst., 37, 395 (1966).

  2. Vogt, P. K., in Adv. Virus Res. (edit. by Smith, Kenneth M., and Lauffer, Max A.), 11, 293 (Academic Press, New York and London, 1965).

    Google Scholar 

  3. Vogt, P. K., in Nat. Cancer Inst. Monog. (edit. by Beard, Joseph W.), 17, 523 (US Government Printing Office, 1964).

    Google Scholar 

  4. Moloney, J. B., in Ann. Rev. Med. (edit. by Degraff, Arthur), 15, 383 (Annual Reviews, Inc., Palo Alto, 1964).

    Google Scholar 

  5. Bernhard, W., Cancer Res., 20, 712 (1960).

    CAS  PubMed  Google Scholar 

  6. Blair, P. B., in Current Topics in Microbiology and Immunology (in the press, 1968).

    Google Scholar 

  7. Robinson, W. S., and Duesberg, P. H., in Molecular Basis of Virology (edit. by Fraenkel-Conrat, H.), 3B, 306 (Reinhold Publishing Co., New York, 1968).

    Google Scholar 

  8. Temin, H. M., Virology, 20, 577 (1963).

    Article  CAS  Google Scholar 

  9. Bader, J. P., Virology, 22, 462 (1964).

    Article  CAS  Google Scholar 

  10. Duesberg, P. H., and Robinson, W. S., Virology, 31, 743 (1967).

    Article  Google Scholar 

  11. Robinson, W. S., Pitkanen, A., and Rubin, H., Proc. US Nat. Acad. Sci., 54, 137 (1965).

    Article  CAS  ADS  Google Scholar 

  12. Galibert, F., Bernard, C., Chenaille, P., and Boiron, M., CR Acad. Sci., 261, 1771 (1965).

    CAS  Google Scholar 

  13. Duesberg, P., and Robinson, W. S., Proc. US Nat. Acad. Sci., 55, 219 (1966).

    Article  CAS  ADS  Google Scholar 

  14. Mora, P. T., McFarland, V. W., and Luborsky, S. W., Proc. US Nat. Acad. Sci., 55, 438 (1966).

    Article  CAS  ADS  Google Scholar 

  15. Duesberg, P. H., and Blair, P. B., Proc. US Nat. Acad. Sci., 55, 1490 (1966).

    Article  CAS  ADS  Google Scholar 

  16. Duesberg, P. H., Proc. US Nat. Acad. Sci., 58, 1511 (1968).

    Article  Google Scholar 

  17. Duesberg, P. H., Robinson, H. L., Robinson, W. S., Huebner, R. J., and Turner, H. C., Virology, 36, 73 (1968).

    Article  CAS  Google Scholar 

  18. Duesberg, P. H., and Robinson, W. S., Proc. US Nat. Acad Sci., 54, 794 (1965).

    Article  CAS  ADS  Google Scholar 

  19. Duesberg, P. H., Proc. US Nat. Acad. Sci., 59, 930 (1968).

    Article  CAS  ADS  Google Scholar 

  20. Spirin, A. S., in Prog. Nucleic Acid Res. (edit. by Davidson, J. N., and Cohn, Waldo E.), 1, 301 (Academic Press, New York and London, 1963).

    Google Scholar 

  21. Martin, R. G., and Ames, B. N., J. Biol. Chem., 236, 1372 (1961).

    CAS  PubMed  Google Scholar 

  22. Duesberg, P. H., and Cardiff, R. C., Virology (in the press).

Download references

Author information

Authors and Affiliations

  1. Virus Laboratory, University of California, Berkeley, California

    CAROL D. BLAIR & PETER H. DUESBERG

Authors
  1. CAROL D. BLAIR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. PETER H. DUESBERG
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BLAIR, C., DUESBERG, P. Structure of Rauscher Mouse Leukaemia Virus RNA. Nature 220, 396–399 (1968). https://doi.org/10.1038/220396a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/220396a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing