Abstract
LESIONS of scrapie are confined to the central nervous system. Differences in the distribution of these lesions have been described for the two strains of scrapie agent used in goats1 and for the lesions which arise as a result of injecting mice with boiled and unboiled material2. We have also collected unpublished data showing wide variation in the distribution of lesions which result from using different strains of the agent in mice or by inoculating, different genotypes of mice with the same agent.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Zlotnik, I., Acta Neuropathol., suppl. 1, 61 (1962).
Zlotnik, I., and Rennie, J. C., Brit. J. Exp. Pathol., 48, 171 (1967).
Fraser, H., and Dickinson, A. G., J. Comp. Pathol. (in the press).
Dickinson, A. G., Meikle, V. M. H., and Fraser, H., J. Comp. Pathol. (in the press).
Eklund, C. M., Kennedy, R. C., and Hadlow, W. J., J. Infect. Dis., 117, 15 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FRASER, H., DICKINSON, A. Distribution of Experimentally Induced Scrapie Lesions in the Brain. Nature 216, 1310–1311 (1967). https://doi.org/10.1038/2161310a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2161310a0
This article is cited by
-
Emergence of CWD strains
Cell and Tissue Research (2023)
-
Evidence of distinct α-synuclein strains underlying disease heterogeneity
Acta Neuropathologica (2021)
-
PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
Acta Neuropathologica (2016)
-
Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties
The EMBO Journal (2013)
-
Prions: health scare and biological challenge
Nature Reviews Molecular Cell Biology (2001)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
