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Stress-induced Suppression of Interferon Production in Virus-infected Mice

Nature volume 205, pages 623–624 (1965)Cite this article

Abstract

INCREASED susceptibility to various viruses has been observed in mice exposed to psychological stress1, in which adrenal hyperactivity is considered to be a mediator. The decrease in resistance of stressed mice to vesicular stomatitis virus (VSV) appears not to be related to impairment of antibody response2. Interferon has been proposed as an important factor in recovery from viral infections3, and interferon production in the chick embryo is inhibited by exogenous corticoid4. For these reasons, the following experiments were performed to determine whether the levels of interferon produced in vivo differ between stressed and unstressed mice infected with viruses.

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References

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Author notes

  1. SHUEH-SHEN CHANG: Post-doctoral Fellow of the U.S. National Academy of Sciences.

Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Los Angles

    SHUEH-SHEN CHANG & A. F. RASMUSSEN JUN.

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  1. SHUEH-SHEN CHANG
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  2. A. F. RASMUSSEN JUN.
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CHANG, SS., RASMUSSEN, A. Stress-induced Suppression of Interferon Production in Virus-infected Mice. Nature 205, 623–624 (1965). https://doi.org/10.1038/205623a0

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