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Reagin-like Antibodies in Animals Immune to Helminth Parasites

Nature volume 204, pages 91–92 (1964)Cite this article

Abstract

RECENT investigations here have shown that rats, monkeys and sheep infected with helminth parasites produce an antibody with many of the properties of human reagin. Naturally occurring persistent antibodies of this type have not been demonstrated previously in animals, although in rats an antibody similar in its biological properties but transitory in appearance can be stimulated when antigen is injected with Haemophilus pertussis killed organisms as adjuvant1,2. Like human reagins3, the antibodies stimulated by helminth infections become rapidly and apparently permanently attached to the skin of animals of the species in which they are stimulated, but they are incapable of sensitizing guineapig skin in passive cutaneous anaphylaxis.

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References

  1. Mota, I., Life Sciences, 1, 465 (1963).

    Article  Google Scholar 

  2. Binaghi, R. A., and Benacerraf, B., J. Immunol., 92, 920 (1964).

    CAS  PubMed  Google Scholar 

  3. Stanworth, D. R., Adv. Immunol., 3, 181 (1963).

    Article  CAS  Google Scholar 

  4. Ovary, Z., and Bier, O., Proc. Soc. Exp. Biol. and Med., 81, 584 (1952).

    Article  CAS  Google Scholar 

  5. Mota, I., Life Sciences, 12, 917 (1963).

    Article  CAS  Google Scholar 

  6. West, G. B., Int. Arch. Allergy, 15, 231 (1959).

    Article  CAS  Google Scholar 

  7. Ogilvie, B. M., Ph.D. thesis, Camb. (1964).

  8. Cooke, R. A., Barnard, J. H., Hebald, S., and Stull, A., J. Exp. Med., 62, 733 (1935).

    Article  CAS  Google Scholar 

  9. Soulsby, E. J. L., in Gell, P. G. H., and Coombs, R. R. A., Clinical Aspects of Immunology (Blackwell, Oxford, 1963).

    Google Scholar 

  10. Archer, R. K., The Eosinophil Leucocyte (Blackwell, Oxford, 1963).

    Google Scholar 

  11. Briggs, N. T., J. Infect. Dis., 113, 22 (1963).

    Article  CAS  Google Scholar 

  12. Augustin, R., and Ridges, A. P., in Garnham, P. C. C., Pierce, A. E., and Roitt, I., immunity to Protozoa: a Symposium of the British Society for Immunology (Blackwell, Oxford, 1963).

    Google Scholar 

Download references

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Author notes

  1. BRIDGET M. OGILVIE: Wellcome Veterinary Research Fellow.

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  1. National Institute for Medical Research, London, N.W.7

    BRIDGET M. OGILVIE

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  1. BRIDGET M. OGILVIE
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OGILVIE, B. Reagin-like Antibodies in Animals Immune to Helminth Parasites. Nature 204, 91–92 (1964). https://doi.org/10.1038/204091a0

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