Abstract
PIPERAZINE is the drug most commonly used for the treatment of ascariasis, in preference to other anthelmintics, because it produces a flaccid paralysis of the parasites1 rather than hyperactivity. Though no direct evidence was available, it was suggested that such paralysis might be due to a curare-like effect, since piperazine prevents the stimulating action of acetylcholine on Ascaris muscle2.
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References
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DEL CASTILLO, J., MORALES, T. & SANCHEZ, V. Action of Piperazine on the Neuromuscular System of Ascaris lumbricoides. Nature 200, 706–707 (1963). https://doi.org/10.1038/200706a0
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DOI: https://doi.org/10.1038/200706a0
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