Abstract
TENUAZONIC acid (I) was first isolated by Rosett et al.1 from culture filtrates of various strains of Alternaria tenuis. The recent report2 of antitumour activity of tenuazonic acid prompts us to report our results with this mould metabolite. During an antiviral screening programme culture filtrates of an Aspergillus were found to inhibit the cytopathic effect of measles virus in HEp2 (Moore) cell cultures (and to exhibit antibacterial activity referable to penicillins). An antiviral compound which later was shown to be tenuazonic acid was isolated from these filtrates. Isolation was assisted by measles and poliovirus plaque tests.
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References
Rosett, T., Sankhala, R., Stickings, C., Taylor, M., and Thomas, R., BioChem. J., 67, 390 (1957).
Kaczka, E. A., Smith, M. C., and Folkers, K., Fed. Proc., 22, No.2, Part 1, 306 (1963). Shigeura, H. T., ibid., 22, 306 (1963).
Stickings, C. E., Biochem. J., 72, 332 (1959).
Lacey, R. N., J. Chem. Soc., 850 (1954).
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MILLER, F., RIGHTSEL, W., SLOAN, B. et al. Antiviral Activity of Tenuazonic Acid. Nature 200, 1338–1339 (1963). https://doi.org/10.1038/2001338a0
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DOI: https://doi.org/10.1038/2001338a0
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