Abstract
THE production of large quantities of tetanus toxin for human immunization was greatly facilitated by the isolation of the highly toxigenic Harvard strain of Cl. tetani by the late Dr. J. H. Mueller and by his success in the provision of a medium suited to this strain. This preliminary report concerns the adaptation of small-scale experimental work to large-scale semi-continuous production, and since it has been possible to reproduce in large vessels the results obtained in 6 in. × 1 in. test-tubes it may be of help to others to describe the lines we have followed and the results that have been obtained.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mueller, J. H., and Miller, P. A., J. Immunol., 50, 377 (1945).
Mueller, J. H., and Miller, P. A., J. Bact., 67, 271 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
THOMSON, R. A Semi-continuous Method for the Large-scale Production of Tetanus Toxin. Nature 180, 1126–1127 (1957). https://doi.org/10.1038/1801126a0
Issue Date:
DOI: https://doi.org/10.1038/1801126a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
