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The Antigenic Stimulus in Transplantation Immunity

Nature volume 178, pages 514–519 (1956)Cite this article

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References

  1. Barnes, A. D., and Krohn, P. L. (personal communication).

  2. Billingham, R. E., Brent, L., Medawar, P. B., and Sparrow, E. M., Proc. Roy. Soc., B, 143, 43 (1954).

    Article  ADS  CAS  Google Scholar 

  3. Billingham, R. E., Brent, L., and Medawar, P. B., Proc. Roy. Soc., B., 143, 58 (1954).

    Article  ADS  CAS  Google Scholar 

  4. Billingham, R. E., Brent, L., and Medawar, P. B., Phil. Trans. Roy. Soc., B, 239, 357 (1956).

    Article  ADS  Google Scholar 

  5. The important discovery that grafts from male mice are eventually rejected by females of the same strain—see Eichwald, E. J., and Silmser, C. R., Transplantation Bull., 2, 148 (1955)—does not affect the design of the present experiments.

    CAS  Google Scholar 

  6. Compare Mizen, N. A., and Petermann, M. L., Cancer Res., 12, 727 (1952).

    Google Scholar 

  7. We are obliged to Dr. A. S. McFarlane for allowing us to use the instrument in the Biophysics Department of the National Institute for Medical Research.

  8. See, for example, Gale, E. F., and Folkes, J. P., Nature, 173, 1223 (1954).

    Article  ADS  CAS  Google Scholar 

  9. Schneider, W. C., and Petermann, M. L., Cancer Res., 10, 751 (1950).

    CAS  PubMed  Google Scholar 

  10. Hogeboom, G. H., Schneider, W. C., and Pallade, G. E., J. Biol. Chem., 172, 619 (1948).

    CAS  PubMed  Google Scholar 

  11. Gilbert, L. M., Overend, W. G., and Webb, M., Exp. Cell Res., 2, 349 (1951).

    Article  CAS  Google Scholar 

  12. Stern, K. G., and Davis, S., Fed. Proc., 5, 156 (1946). Stern, K. G., Goldstein, G., Wagman, J., and Schryver, J., Fed. Proc., 6, 296 (1947). See also Carter, R. O., and Hall, J. L., J. Amer. Chem. Soc., 62, 1194 (1940).

    CAS  PubMed  Google Scholar 

  13. Cohen, S. S., J. Biol Chem., 158, 255 (1945).

    CAS  Google Scholar 

  14. Compare the experiments of Gale and Folkes (ref. 8) and of Allfrey, V. G., and Mirsky, A. E., Nature, 176, 1042 (1955).

    Article  ADS  CAS  Google Scholar 

  15. Unpublished observations.

  16. Greene, R. W., Proc. Soc. Exp. Biol. Med. N.Y., 87, 412 (1954). Humphrey, J. H., Nature, 176, 38 (1955).

    Article  CAS  Google Scholar 

  17. Shooter, K. V., Davison, P. F., and Butler, J. A. V., Biochim. Biophys. Acta, 13, 192 (1954).

    Article  CAS  Google Scholar 

  18. Bernstein, M. H., and Mazia, D., Biochim. Biophys. Acta, 11, 59 (1953).

    Article  CAS  Google Scholar 

  19. Wang, T. Y., Mayer, D. T., and Thomas, L. E., Exp. Cell. Res., 4, 102 (1953). Engbring, V. E., and Laskowski, M., Biochim. Biophys. Acta, 11, 244 (1953).

    Article  CAS  Google Scholar 

  20. Review by Snell, G. D., J. Nat. Cancer Inst., 14, 691 (1953). Amos, B., Gorer, P. A., and Mikulska, Z. B., Proc. Roy. Soc., B, 144, 369 (1955).

    Google Scholar 

  21. Gorer, P. A., J. Path. Bact., 44, 691 (1937); 54, 51 (1942); Brit. J. Cancer, 2, 103 (1948); see also ref. 20.

    Article  Google Scholar 

  22. Mitchison, N. A., J. Genet., 51, 406 (1953).

    Article  Google Scholar 

  23. Mitchison, N. A., and Dube, O. L., J. Exp. Med., 102, 179 (1955). Algire, G. H., Weaver, J. M., and Prehn, R. T., J. Nat. Cancer Inst., 15, 493 (1954). Weaver, J. M., Algire, G. H., and Prehn, R. T., J. Nat. Cancer Inst., 15, 1737 (1955).

    Article  Google Scholar 

  24. Bollag, W., Experientia, 12, 57 (1956).

    Article  CAS  Google Scholar 

  25. Darcy, D. A., J. Path. Bact., 70, 143 (1955).

    Article  CAS  Google Scholar 

  26. We discuss the bearing of this work on the phenomenon of ‘enhancement’ in Transplantation Bull., 3, 84 (1956).

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Author notes

  1. R. E. BILLINGHAM: Research Fellow of the British Empire Cancer Campaign.

Authors and Affiliations

  1. University College, London,

    R. E. BILLINGHAM,  L. BRENT &  P. B. MEDAWAR

Authors
  1. R. E. BILLINGHAM
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  2. L. BRENT
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  3. P. B. MEDAWAR
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BILLINGHAM, R., BRENT, L. & MEDAWAR, P. The Antigenic Stimulus in Transplantation Immunity. Nature 178, 514–519 (1956). https://doi.org/10.1038/178514a0

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