Abstract
THE genetic analysis of species differences is of especial interest in precisely those cases where the sterility or inviability of the hybrids between the species stands in the way of such analysis. A notable case of this kind is that of Drosophila melanogaster and simulans, species which otherwise would present most favourable conditions for detailed analysis, on account of the already existing knowledge of the genetics of each species and the existence of abundant stocks providing suitable genetic tools (‘markers’). We have found a means of circumventing the sterility of the F1 hybrids between these species and thus obtaining types of the same kind as would be produced in a backcross of the F1 hybrid, were it fertile, to melanogaster; it is at the same time possible to recognize, by means of the markers used, what combination of chromosomes is present in the pseudo-backcross progeny and thus to determine the effects of the different chromosome combinations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Muller, H. J., J. Genetics, 40, 1–66 (1940).
Pontecorvo, G., Ph.D. thesis, University of Edinburgh. 146 pp- (also Muller and Pontecorvo, unpublished)(1940).
Sturtevant, A. H., Genetics, 5, 488–500 (1920).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MULLER, H., PONTECORVO, G. Recombinants between Drosophila Species the F1 Hybrids of which are Sterile. Nature 146, 199–200 (1940). https://doi.org/10.1038/146199b0
Issue Date:
DOI: https://doi.org/10.1038/146199b0
This article is cited by
-
Genetic mechanisms preventing the fusion of ecotypes even in the face of gene flow
Scientific Reports (2012)
-
Fine mapping and candidate gene analysis of hwh1 and hwh2, a set of complementary genes controlling hybrid breakdown in rice
Theoretical and Applied Genetics (2008)
-
Hermann Joseph Muller, Evolutionist
Nature Reviews Genetics (2005)
-
Now blows the east wind
Nature (1996)
-
Rescue of hybrid sterility in crosses between D. melanogaster and D. simulans
Nature (1996)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.