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Integration of endoplasmic reticulum signaling in health and disease

Nature Medicine volume 5, pages 745–751 (1999)Cite this article

Abstract

Alteration in the endoplasmic reticulum processing of cargo molecules by pathogens, or deficiencies in cargo handling by the endoplasmic reticulum machinery in a broad range of diseases including cystic fibrosis, hemochromatosis and neuropathies such as Alzheimer disease demonstrates an unanticipated role of the endoplasmic reticulum in the control of cell fate.

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Figure 1: Receptors in the ER coordinate gene expression with cell function.
Figure 2: Viral and bacterial pathogens manipulate ER function to escape immune surveillance.
Figure 3: Effect of disorders in protein conformation on ER export.
Figure 4: Integrative processing by the ER.

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  80. Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037.

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  1. Departments of Cell and Molecular Biology, 10550 N. Torrey Pines Road/IMMI, La Jolla, 92037, California, USA

    Meir Aridor, William E. Balch & William E. Balch

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Aridor, M., Balch, W. Integration of endoplasmic reticulum signaling in health and disease. Nat Med 5, 745–751 (1999). https://doi.org/10.1038/10466

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