Low levels of DNA damage caused by oxidative stress can be repaired, whereas extensive damage usually results in cell death. p53 contributes to both outcomes by stimulating expression of either pro- or antioxidant genes (pages 1306–1313).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression
Cell Death & Disease Open Access 06 April 2021
-
The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers
Scientific Reports Open Access 26 May 2016
-
Metabolic regulation by p53
Journal of Molecular Medicine Open Access 23 February 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sengupta, S. & Harris, C.C. Nat. Rev. Mol. Cell. Biol. 6, 44–55 (2005).
Sablina, A.A. et al. Nat. Med. 11, 1306–1313 (2005).
Lane, D.P. Nature 358, 15–16 (1992).
Martindale, J.L. & Holbrook, N.J. J. Cell. Physiol. 192, 1–15 (2002).
Budanov, A.V. et al. Science 304, 596–600 (2004).
Tan, M. et al. J. Biol. Chem. 274, 12061–12066 (1999).
Polyak, K. et al. Nature 389, 300–305 (1997).
Vousden, K.H. & Lu, X. Nat. Rev. Cancer 2, 594–604 (2002).
Klaunig, J.E. & Kamendulis, L.M. Annu. Rev. Pharmacol. Toxicol. 44, 239–267 (2004).
Behrend, L., Henderson, G. & Zwacka, R.M. Biochem. Soc. Trans. 31, 1441–1444 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bensaad, K., Vousden, K. Savior and slayer: the two faces of p53. Nat Med 11, 1278–1279 (2005). https://doi.org/10.1038/nm1205-1278
Issue Date:
DOI: https://doi.org/10.1038/nm1205-1278
This article is cited by
-
Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression
Cell Death & Disease (2021)
-
The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers
Scientific Reports (2016)
-
Augmentation of oxidative stress-induced apoptosis in MCF7 cells by ascorbate–tamoxifen and/or ascorbate–juglone treatments
In Vitro Cellular & Developmental Biology - Animal (2016)
-
The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials
Archives of Toxicology (2015)
-
Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression
International Journal of Obesity (2014)