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Cardiolipin oxidation sets cytochrome c free

Nature Chemical Biology volume 1, pages 188–189 (2005)Cite this article

Cytochrome c release from the mitochondria is a critical component of the apoptotic cell-death program. Cytochrome c–catalyzed peroxidation of cardiolipin, a mitochondrial phospholipid, has now been shown to lessen the binding of cytochrome c to the mitochondrial inner membrane and facilitate permeabilization of the outer membrane. These results describe a new and earlier pro-apoptotic role for cytochrome c.

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Figure 1: Mechanisms of cytochrome c liberation from mitochondria in apoptosis.

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Authors and Affiliations

  1. Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden

    Sten Orrenius & Boris Zhivotovsky

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  1. Sten Orrenius
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  2. Boris Zhivotovsky
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Orrenius, S., Zhivotovsky, B. Cardiolipin oxidation sets cytochrome c free. Nat Chem Biol 1, 188–189 (2005). https://doi.org/10.1038/nchembio0905-188

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