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Relaxed specificity in aromatic prenyltransferases

Prenylation represents a critical step in the biosynthesis of many natural products. A new study reveals how aromatic prenyltransferase enzymes tolerate diverse aromatic polyketides while still controlling the length of prenyl side chains.

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Figure 1: Structure of the aromatic prenyltransferase Orf2, from Streptomyces, complexed with aromatic and prenyl substrates.

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References

  1. Ortholand, J.-Y. & Ganesan, A. Curr. Opin. Chem. Biol. 8, 271–280 (2004).

    Article  CAS  Google Scholar 

  2. Shin-ya, K. et al. Tetrahedron Lett. 31, 6025–6026 (1990).

    Article  CAS  Google Scholar 

  3. Kuzuyama, T., Noel, J. P. & Richard, S. B. Nature 435, 983–987 (2005).

    Article  CAS  Google Scholar 

  4. Liang, P.H., Ko, T.P. and Wang, A.H Eur. J. Biochem. 269, 3339–3354 (2002)

    Article  CAS  Google Scholar 

  5. Pojer, F. et al. Proc. Natl. Acad. Sci. USA 100, 2316–2321 (2003).

    Article  CAS  Google Scholar 

  6. Nagano, N., Hutchinson, E.G. & Thornton, J.M. Prot. Sci. 8, 2072–2084 (1999).

    Article  CAS  Google Scholar 

  7. Wierenga, R.K. FEBS Letters 492, 193–198 (2001).

    Article  CAS  Google Scholar 

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Koehl, P. Relaxed specificity in aromatic prenyltransferases. Nat Chem Biol 1, 71–72 (2005). https://doi.org/10.1038/nchembio0705-71

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  • DOI: https://doi.org/10.1038/nchembio0705-71

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