Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Beam me up, Scottie! TREK channels swing both ways

TREK1 was known as a voltage-independent 'background' potassium channel, but a new study suggests that protein kinase A can reversibly convert it to a voltage-dependent state.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: At rest (left), unphosphorylated TREK1 channels help set the resting membrane potential.

Bob Crimi

References

  1. Bockenhauer, D., Zilberberg, N. & Goldstein, S. A. N. Nat. Neurosci. 4, 486–491 (2001).

    Article  CAS  Google Scholar 

  2. Weight, F. F. & Votava, J. Science 170, 755–758 (1970).

    Article  CAS  Google Scholar 

  3. Katayama, Y. & North, R. A. Nature 274, 387–388 (1978).

    Article  CAS  Google Scholar 

  4. Castellucci, V. & Kandel, E. R. Science 194, 1176–1178 (1976).

    Article  CAS  Google Scholar 

  5. Klein, M. & Kandel, E. R. Proc. Natl. Acad. Sci. USA 77, 6912–6916 (1980).

    Article  CAS  Google Scholar 

  6. Siegelbaum, S. A., Camardo, J. S. & Kandel, E. R. Nature 299, 413–417 (1982).

    Article  CAS  Google Scholar 

  7. Lesage, F. & Lazdunski, M. Am. J. Physiol. Renal Physiol. 279, F793–801 (2000).

    Article  CAS  Google Scholar 

  8. North, R. A. Trends Neurosci. 23, 234–235 (2000).

    Article  CAS  Google Scholar 

  9. Millar, J. A. et al. Proc. Natl. Acad. Sci. USA 97, 3614–3618 (2000).

    Article  CAS  Google Scholar 

  10. Talley, E. M., Lei, Q., Sirois, J. E. & Bayliss, D. A. Neuron 25, 399–410 (2000).

    Article  CAS  Google Scholar 

  11. Buckler, K. J., Williams, B. A. & Honore, E. J. Physiol. (Lond.) 525, 135–142 (2000).

    Article  CAS  Google Scholar 

  12. Patel, A. J. et al. EMBO J. 17, 4283–4290 (1998).

    Article  CAS  Google Scholar 

  13. Maingret, F. et al. EMBO J. 19, 2483–2491 (2000).

    Article  CAS  Google Scholar 

  14. Backx, P. H. & Marban, E. Circ. Res. 72, 890–900 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maylie, J., Adelman, J. Beam me up, Scottie! TREK channels swing both ways. Nat Neurosci 4, 457–458 (2001). https://doi.org/10.1038/87402

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/87402

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing