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Ion channels

Swimming with sperm

Nature volume 413, pages 579–581 (2001)Cite this article

Mice become infertile if they lack the gene encoding a newly discovered sperm-specific ion channel. Sperm are produced in normal quantities, but have trouble moving.

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Figure 1: Changes in sperm motility, from production to fertilization.

References

  1. Wennemuth, G., Westenbroek, R. E., Xu, T., Hille, B. & Babcock, D. F. J. Biol. Chem. 275, 21210–21217 (2000).

    Article  CAS  Google Scholar 

  2. Ren, D. et al. Nature 413, 603–609 (2001).

    Article  ADS  CAS  Google Scholar 

  3. Suarez, S. S. J. Androl. 17, 331–335 (1996).

    CAS  PubMed  Google Scholar 

  4. Jungnickel, M. K., Marrero, H., Birnbaumer, L., Lemos, J. R. & Florman, H. M. Nature Cell Biol. 3, 499–502 (2001).

    Article  CAS  Google Scholar 

  5. Quill, T. A., Ren, D., Clapham, D. E. & Garbers, D. L. Proc. Natl Acad. Sci. USA (in the press).

  6. Mengerink, K. J., Moy, G. W. & Vacquier, V. D. Zygote 8, S28–S30 (2000).

    Article  Google Scholar 

  7. Emmens, S. W. & Somlo, S. Nature 401, 339–340 (1999).

    Article  ADS  Google Scholar 

  8. Zippin, J. H., Levin, L. R. & Buck, J. Trends Endocrinol. Metab. 12, 366–370 (2001).

    Article  CAS  Google Scholar 

  9. Okamura, N., Tajima, Y. & Sugita, Y. in New Horizons in Sperm Cell Research (ed. Mohri, H.) 197–203 (Japan. Sci. Soc. Press, Tokyo, 1987).

  10. Garbers, D. L. Annu. Rev. Biochem. 58, 719–742 (1989).

    Article  CAS  Google Scholar 

  11. Serres, P. C. & Jouannet, P. Biol. Cell 92, 255–266 (2000).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, Cecil H. & Ida Green Center for Reproductive Biology Sciences, Howard Hughes Medical Institute, and the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9051, Texas, USA

    David L. Garbers

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  1. David L. Garbers
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Correspondence to David L. Garbers.

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Garbers, D. Swimming with sperm. Nature 413, 579–581 (2001). https://doi.org/10.1038/35098164

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