Abstract
DNA sequencing shows that the intragenic duplication within the human haptoglobin Hp2 allele was formed by a non-homologous, probably random, crossing-over within different introns of two Hp1genes, probably in an Hp1F/Hp1S heterozygote.
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References
Smithies, O. Nature 175, 307 (1955).
Smithies, O. & Walker, N. F. Nature 176, 1265–1266 (1955).
Smithies, O. & Walker, N. F. Nature 178, 694–695 (1956).
Connell, G. E., Dixon, G. H. & Smithies, O. Nature 193, 505–506 (1962).
Smithies, O., Connell, G. E. & Dixon, G. H. Am. J. hum. Genet. 14, 14–21 (1962).
Smithies, O., Connell, G. E. & Dixon, G. H. Nature 196, 232–236 (1962).
Nance, W. E. & Smithies, O. Nature 198, 869–870 (1963).
vander Straten, A., Herzog, A., Jacobs, P., Cabezon, T. & Bollen, A. EMBO J. 2, 1003–1007 (1983).
Yang, F., Brune, J. L., Baldwin, W. D., Barnett, D. R. & Bowman, B. H. Proc. natn. Acad. Sci. U.S.A. 80, 5875–5879 (1983).
Raugei, G. et al. Nucleic Acids Res. 11, 5811–5819 (1983).
Barnett, D. R. et al. Protides of the Biological Fluids, 22nd Colloq. (ed. Peelers, H.) 589 (Pergamon, New York, 1975).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Loenen, W. A. M. & Blattner, F. R. Gene 26, 171–179 (1983).
Hohn, B. Meth. Enzym. 68, 299–309 (1979).
Maeda, N., Bliska, J. B. & Smithies, O. Proc. natn. Acad. Sci. U.S.A. 80, 5012–5016 (1983).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
Black, J. A. & Dixon, G. H. Nature 218, 736–742 (1968).
Nordheim, A. & Rich, A. Proc. natn. Acad. Sci. U.S.A. 80, 1821–1825 (1983).
Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).
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Maeda, N., Yang, F., Barnett, D. et al. Duplication within the haptoglobin Hp2 gene. Nature 309, 131–135 (1984). https://doi.org/10.1038/309131a0
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DOI: https://doi.org/10.1038/309131a0
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