Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

β-Sheet topology and the relatedness of proteins

Nature volume 268, pages 495–500 (1977)Cite this article

Abstract

The topological connectivities of β-pleated sheets in the known protein structures are systematically surveyed for regularly occurring features. The many empirical restrictions found and the distribution of actually occurring topologies among the hypothetically possible ones suggest that striking topological similarities between different proteins can readily happen by chance.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Chothia, C. J. molec. Biol. 75, 295–302 (1973).

    Article  CAS  PubMed  Google Scholar 

  2. Richardson, J. S. Proc. natn. Acad. Sci. U.S.A. 73, 2619–2623 (1976).

    Article  ADS  CAS  Google Scholar 

  3. Sternberg, M. J. E. & Thornton, J. M. J. molec. Biol. 105, 367–382 (1976).

    Article  CAS  PubMed  Google Scholar 

  4. Chothia, C. & Levitt, M. Nature 261, 552–558 (1976).

    Article  PubMed  Google Scholar 

  5. Schulz, G. E. & Schirmer, R. H. Nature 250, 142–144 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Richardson, J. S., Richardson, D. C., Thomas, K. A., Silverton, E. W. & Davies, D. R. J. molec. Biol. 102, 221–235 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. Rossman, M. G. & Argos, P. J. molec. Biol. 105, 75–96 (1976).

    Article  Google Scholar 

  8. Fenna, R. E. & Matthews, B. W. Brookhaven Symp. Biol. 28 (in the press).

  9. Liljas, A. et al. Nature new Biol. 235, 131–137 (1972).

    Article  CAS  PubMed  Google Scholar 

  10. Moras, D. et al. J. biol. Chem. 250, 9137–9162 (1975).

    CAS  PubMed  Google Scholar 

  11. Poljak, R. J., Amzel, L. M., Chen, B. L., Phizackerly, R. P. & Saul, F. Proc. natn. Acad. Sci. U.S.A. 71, 3440–3444 (1974).

    Article  ADS  CAS  Google Scholar 

  12. Richardson, J. S., Thomas, K. A., Rubin, B. H. & Richardson, D. C. Proc. natn. Acad. Sci. U.S.A. 72, 1349–1353 (1975).

    Article  ADS  CAS  Google Scholar 

  13. Blake, C. C. F., Geisow, M. J., Swan, I. D. A., Rerat, C. & Rerat, B. J. molec. Biol. 88, 1–12 (1974).

    Article  CAS  PubMed  Google Scholar 

  14. Quicho, F. A. & Lipscomb, W. N. Adv. Protein Chem. 25, 1–78 (1971).

    Article  Google Scholar 

  15. Banner, D. W. et al. Nature 255, 609–614 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Reeke, G. N., Jr, Becker, J. W. & Edelman, G. M. J. biol. Chem. 250, 1525–1547 (1975).

    CAS  PubMed  Google Scholar 

  17. Alden, R. A., Birktoft, J. J., Kraut, J., Robertus, J. D. & Wright, C. S. Biochem. biophys. Res. Commun. 45, 337–344 (1971).

    Article  CAS  PubMed  Google Scholar 

  18. Birktoft, J. J. & Blow, D. M. J. molec. Biol. 68, 187–240 (1972).

    Article  CAS  PubMed  Google Scholar 

  19. Campbell, J. W., Watson, H. C. & Hodgson, G. I. Nature 250, 301–303 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Blake, C. C. F. Essays Biochem. 11, 37–79 (1975).

    CAS  PubMed  Google Scholar 

  21. Watenpaugh, K. D., Sieker, L. C., Herriott, J. R. & Jensen, L. H. Acta Crystallogr. B 29, 943–956 (1973).

    Article  CAS  Google Scholar 

  22. Sweet, R. M., Wright, H. T., Janin, J., Chothia, C. H. & Blow, D. M. Biochemistry 13, 4212–4228 (1974).

    Article  CAS  PubMed  Google Scholar 

  23. Drenth, J., Jansonius, J. N., Koekoek, R. & Wolthres, B. G. Adv. Protein Chem. 25, 79–115 (1971).

    Article  CAS  PubMed  Google Scholar 

  24. Steitz, T. A. Coordinates in Protein Data Bank, (Brookhaven National Laboratory, Upton, Long Island, New York 1973).

    Google Scholar 

  25. Chandrasekhar, K., McPherson, A., Adams, M. J. & Rossmann, M. G. J. molec. Biol. 76, 503–528 (1973).

    Article  CAS  PubMed  Google Scholar 

  26. Brändén, C.-I. Coordinates in Protein Data Bank, Brookhaven National Laboratory, Upton, Long Island, New York (1973).

  27. Low, B. W. et al. Proc. natn. Acad. Sci. U.S.A. 73, 2991–2994 (1976).

    Article  ADS  CAS  Google Scholar 

  28. Mathews, F. S., Levine, M. & Argos, P. J. molec. Biol. 64, 449–464 (1972).

    Article  CAS  PubMed  Google Scholar 

  29. Holmgren, A., Söderberg, B.-O., Eklund, H. & Brändén, C.-I. Proc. natn. Acad. Sci. U.S.A. 72, 2305–2309 (1975).

    Article  ADS  CAS  Google Scholar 

  30. Anderson, R. D. et al. Proc. natn. Acad. Sci. U.S.A. 69, 3189–3191 (1972).

    Article  ADS  Google Scholar 

  31. Arnone, A. et al. J. biol. Chem. 246, 2302–2316 (1971).

    CAS  PubMed  Google Scholar 

  32. Wyckoff, H. W. et al. J. biol. Chem. 245, 305–328 (1970).

    CAS  PubMed  Google Scholar 

  33. Colman, P. M., Jansonius, J. N. & Matthews, B. W. J. molec. Biol. 70, 701–724 (1972).

    Article  CAS  PubMed  Google Scholar 

  34. Bergsma, J. et al. J. molec. Biol. 98, 637–643 (1975).

    Article  CAS  PubMed  Google Scholar 

  35. Schulz, G. E., Elzinga, M., Marx, F. & Schirmer, R. H. Nature 250, 120–123 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Imoto, T., Johnson, L. M., North, A. C. T., Phillips, D. C. & Rupley, J. A. The Enzymes 7, 665–868 (1972).

    Article  CAS  Google Scholar 

  37. Matthews, B. W. & Remington, S. J. Proc. natn. Acad. Sci. U.S.A. 71, 4178–4182 (1974).

    Article  ADS  CAS  Google Scholar 

  38. Carter, C. W. et al. J. biol. Chem. 249, 4212–4225 (1974).

    CAS  PubMed  Google Scholar 

  39. Deisenhofer, J. & Steigemann, W. Acta Crystallogr. B 31, 238–250 (1975).

    Article  Google Scholar 

  40. Adman, E. T., Seiker, L. C. & Jensen, L. H. J. biol. Chem. 248, 3987–3996 (1973).

    CAS  PubMed  Google Scholar 

  41. Bryant, T. N., Watson, H. C. & Wendell, P. L. Nature 247, 14–17 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Wetlaufer, D. B. Proc. natn. Acad. Sci. U.S.A. 70, 697–701 (1973).

    Article  ADS  CAS  Google Scholar 

  43. Nagano, K. J. molec. Biol. 84, 337–372 (1974).

    Article  CAS  PubMed  Google Scholar 

  44. Ptitsyn, O. B. & Rashin, A. A. Biophys. Chem. 3, 1–20 (1975).

    Article  CAS  PubMed  Google Scholar 

  45. Tanaka, S. & Scheraga, H. A. Proc. natn. Acad. Sci. U.S.A. 72, 3802–3806 (1975).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, Duke University, Durham, North Carolina, 27710

    Jane S. Richardson

Authors
  1. Jane S. Richardson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Richardson, J. β-Sheet topology and the relatedness of proteins. Nature 268, 495–500 (1977). https://doi.org/10.1038/268495a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/268495a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing