Abstract
A MODEL has been presented showing the contribution of the protein–glycoprotein complex1–3 when transformed cells are agglutinted by lectins4–6. But this has not been possible for the lectin–glycolipid complex because glycolipids form micelles, even at very low concentrations. This difficulty could be overcome by incorporating these glycolipids into lipid vesicles. (Haywood demonstrated that ganglioside incorporated in liposome can provide receptors for sendai virus7.) We have now studied the intercation between a galactose-specific lectin from Ricinus communis beans1,8,9 and liposomes containing different amounts of monosialoganglioside (GM1), and found that the latter can be used as a model system for the investigation of agglutination of cells by lectins.
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SUROLIA, A., BACHHAWAT, B. & PODDER, S. Interaction between lectin from Ricinus communis and liposomes containing gangliosides. Nature 257, 802–804 (1975). https://doi.org/10.1038/257802a0
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DOI: https://doi.org/10.1038/257802a0
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