Abstract
SALISBURY1 has asked how enzymes could arise by natural selection from less developed ancestors if the minimal structural requirements for their activity are so inflexible that variants below a certain high level of development cannot exist. This problem can be resolved by considering the evolution of catalytic rates.
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BLACK, S. Pre-cell Evolution and the Origin of Enzymes. Nature 226, 754–755 (1970). https://doi.org/10.1038/226754a0
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DOI: https://doi.org/10.1038/226754a0
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