Abstract
AbstractSimple tapping and complex movements (Luria finger apposition task) were performed unimanually and bimanually by two groups of professional guitarists while EEG was recorded from electrodes over the sensorimotor cortex. One group had a task-specific movement disorder (focal dystonia or musicians' cramp), while the other group did not (controls). There were no significant group interactions in the task-related power (TRPow) within the alpha range of 8-10Hz (mu1). In contrast, there was a significant group interaction within the alpha range of 10-12Hz (mu2); these latter frequencies are associated with task-specific sensorimotor integration. The significant group interaction included task (simple and complex) by hand (left, right, and both) by electrodes (10 electrodes over the sensorimotor areas). In the rest conditions, the alpha power (10-12Hz) was comparable between the groups; during movement, however, compared to the controls, patients demonstrated the greatest TRPow (10-12Hz) over all conditions. This was particularly evident when patients used their affected hand and suggests that patients with musicians' cramp have impaired task-specific sensorimotor integration.
References
Altenmüller, E. (1998). Causes and cures of focal limb-dystonia in musicians.. International Society for Study of Tension in Performance, 9, 13– 17 .Andres, F.G. , Gerloff, C. (1999). Coherence of sequential movements and motor learning.. Journal of Clinical Neurophysiology, 16, 520– 527 .Andrew, C. , Pfurtscheller, G. (1997). On the existence of different alpha band rhythms in the hand area of man.. Neuroscience Letters, 222, 103– 106 .Babiloni, C. , Carducci, F. , Cincotti, F. , Rossini, P.M. , Neuper, C. , Pfurtscheller, G. , et al. (1999). Human movement-related potentials vs desynchronization of EEG alpha rhythm: A high-resolution EEG study.. Neuroimage, 10, 658– 665 .Berardelli, A. , Rothwell, J.C. , Hallett, M. , Thompson, P. D. , Manfredi, M. , Marsden, C.D. (1998). The pathophysiology of primary dystonia.. Brain, 121, 1195– 1212 .Brinkman, C. (1984). Supplementary motor area of the monkey's cerebral cortex: Short- and long-term deficits after unilateral ablation and the effects of subsequent callosal section.. Journal of Neuroscience, 4, 918– 929 .Cassim, F. , Monaca, C. , Szurhaj, W. , Bourriez, J.L. , Defebvre, L. , Derambure, P. , et al. (2001). Does post-movement beta synchronization reflect an idling motor cortex?. NeuroReport, 12(17), 3859– 3863 .Chen, R. , Hallett, M. (1998). Focal dystonia and repetitive motion disorders.. Clinical Orthopaedics & Related Research, (351), 102– 106 .Chen, R. , Wassermann, E.M. , Hallett, M. (1996). Impairment of cortical inhibition in focal dystonia.. Annals of Neurology, 40, T180– T180‘?quest;’ .Cui, R.Q. , Huter, D. , Egkher, A. , Lang, W. , Lindinger, G. , Deecke, L. (2000). High resolution DC-EEG mapping of the Bereitschaftspotential preceding simple or complex bimanual sequential finger movement.. Experimental Brain Research, 134(1), 49– 57 .Deiber, M.P. , Caldara, R. , Ibanez, V. , Hauert, C.A. (2001). Alpha band power changes in unimanual and bimanual sequential movements, and during motor transitions.. Clinical Neurophysiology, 112, 1419– 1435 .Deuschl, G. , Toro, C. , Matsumoto, J. , Hallett, M. (1995). Movement-related cortical potentials in writer's cramp.. Annals of Neurology, 38, 862– 868 .Donchin, O. , Gribova, A. , Steinberg, O. , Bergman, H. , Vaadia, E. (1998). Primary motor cortex is involved in bimanual coordination.. Nature, 395(6699), 274– 278 .Fahn, S. (1988). Concept and classification of dystonia.. Clinical Neuropharmacology, 9(Supplement 2), S37– S48 .Fahn, S. (1989). Assessment of the primary dystonias.. In T.L. Munsat (Ed.), Quantification of neurologic deficit (pp.241- 270). Stoneham: Butterworth. .Fahn, S. , Bressman, S.B. , Marsden, C.D. (1998). Classification of dystonia.. Advances in Neurology, 78, 1– 10 .Fahn, S. , Marsden, C.D. , Calne, D.B. (1987). Classification and investigation of dystonia.. In C.D. Marsden & S. Fahn (Eds.), Movement disorders 2 (pp.332-358). London: Butterworth. .Fletcher, N.H. , Rossing, T.D. Eds. (1991). The physics of musical instruments. . New York: Springer-Verlag. .Gerloff, C. , Cohen, L.G. , Floeter, M.K. , Chen, R. , Corwell, B. , Hallett, M. (1998). Inhibitory influence of the ipsilateral motor cortex on responses to stimulation of the human cortex and pyramidal tract.. Journal of Physiology, London, 510(1), 249– 259 .Gerloff, C. , Corwell, B. , Chen, R. , Hallett, M. , Cohen, L.G. (1998). The role of the human motor cortex in the control of complex and simple finger movement sequences.. Brain, 121, 1695– 1709 .Gerloff, C. , Richard, J. , Hadley, J. , Schulman, A.E. , Honda, M. , Hallett, M. (1998). Functional coupling and regional activation of human cortical motor areas during simple, internally paced and externally paced finger movements.. Brain, 121, 1513– 1531 .Goerres, G.W. , Samuel, M. , Jenkins, I.H. , Brooks, D.J. (1998). Cerebral control of unimanual and bimanual movements: An H2(15)O PET study.. NeuroReport, 9, 3631– 3638 .Greenhouse, S. , Geisser, S. (1959). On methods in analysis of profile data.. Psychometrika, 24, 95– 112 .Hallett, M. (1998a). The neurophysiology of dystonia.. Archives of Neurology, 55, 601– 603 .Hallett, M. (1998b). Physiology of dystonia.. Advances in Neurology, 78, 11– 18 .Halliday, D.M. , Rosenberg, J.R. , Amjad, A. , Breeze, P. , Conway, B.A. , Farmer, S.F. (1995). A framework for the analysis of mixed time series/point process data - theory and application to the study of physiological tremor, single motor unit discharges and electromyograms.. Progress in Biophysics & Molecular Biology, 64, 237– 278 .Hamano, T. , Kaji, R. , Katayama, M. , Kubori, T. , Ikeda, A. , Shibasaki, H. , et al. (1999). Abnormal contingent negative variation in writer's cramp.. Clinical Neurophysiology, 110, 508– 515 .Hartlage, L.C. , Gage, R. (1997). Unimanual performance as a measure of laterality.. Neuropsychology Review, 7, 143– 156 .Hoshiyama, M. , Kakigi, R. , Berg, P. , Koyama, S. , Kitamura, Y. , Shimojo, M. , et al. (1997). Identification of motor and sensory brain activities during unilateral finger movement: Spatiotemporal source analysis of movement-associated magnetic fields.. Experimental Brain Research, 115(1), 6– 14 .Hummel, F. , Andres, F. , Altenmüller, E. , Dichgans, J. , Gerloff, C. (2002). Inhibitory control of acquired motor programmes in the human brain.. Brain, 125(Part 2), 404– 420 .Kandel, E.R. , Schwartz, J.H. , Jessell, T.M. (1991). Principles of neural science (3rd ed.).. Connecticut: Appleton & Lange. .Kawashima, R. , Matsumura, M. , Sadato, N. , Naito, E. , Waki, A. , Nakamura, S. , et al. (1998). Regional cerebral blood flow changes in human brain related to ipsilateral and contralateral complex hand movements-a PET study.. European Journal of Neuroscience, 10, 2254– 2260 .Kawashima, R. , Yamada, K. , Kinomura, S. , Yamaguchi, T. , Matsui, H. , Yoshioka, S. , et al. (1993). Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement.. Brain Research, 623(1), 33– 40 .Kim, S.G. , Ashe, J. , Hendrick, K. , Ellermann, J.M. , Merkle, H. , Ugurbil, K. , et al. (1993). Functional magnetic resonance imaging of the motor cortex: Hemispheric asymmetry and handedness.. Science, 261, 615– 616 .Lim, V.K. , Altenmüller, E. , Bradshaw, J.L. (2001). Focal dystonia: Current theories.. Human Movement Science, 20, 875– 914 .Luppino, G. , Matelli, M. , Camarda, R. , Rizzolatti, G. (1993). Corticocortical connections of area F3 (SMA-proper) and area F6 (pre-SMA) in the macaque monkey.. Journal of Comparative Neurology, 338(1), 114– 140 .Luria, A.R. (1980). Higher cortical functions in man (2nd ed.).. New York: Basic Books. .Pfurtscheller, G. (1992). Event-related synchronization (ERS): An electrophysiological correlation of cortical areas at rest.. Electroencephalography & Clinical Neurophysiology, 83, 757– 760 .Pfurtscheller, G. (1999). EEG event-related desynchronization (ERD) and event-related synchronization (ERS).. In E. Niedermeyer & F. Lopes Da Silva (Eds.), Electroencephalography: Basic principles, clinical applications, and related fields (4th ed., pp.958-1857). Baltimore: Williams & Wilkins. .Pfurtscheller, G. , Aranibar, A. (1977). Event-related cortical desynchronization detected by power measurements of scalp EEG.. Electroencephalography & Clinical Neurophysiology, 42, 817– 826 .Pfurtscheller, G. , da Silva, F.H.L. (1999). Event-related EEG/MEG synchronization and desynchronization: Basic principles.. Clinical Neurophysiology, 110, 1842– 1857 .Pfurtscheller, G. , Neuper, C. , Krausz, G. (2000). Functional dissociation of lower and upper frequency mu rhythms in relation to voluntary limb movement.. Clinical Neurophysiology, 111, 1873– 1879 .Pulvermuller, F. , Lutzenberger, W. , Preissl, H. , Birbaumer, N. (1995). Motor programming in both hemispheres: An EEG study of the human brain.. Neuroscience Letters, 190(1), 5– 8 .Rao, S.M. , Binder, J.R. , Bandettini, P.A. , Hammeke, T.A. , Yetkin, F.Z. , Jesmanowicz, A. , et al. (1993). Functional magnetic resonance imaging of complex human movements.. Neurology, 43, 2311– 2318 .Ridding, M.C. , Sheean, G. , Rothwell, J.C. , Inzelberg, R. , Kujirai, T. (1995). Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia.. Journal of Neurology, Neurosurgery & Psychiatry, 59, 493– 498 .Ritz, R. , Sejnowski, T.J. (1997). Synchronous oscillatory activity in sensory systems: New vistas on mechanisms.. Current Opinion in Neurobiology, 7, 536– 546 .Rosenkranz, K. , Altenmüller, E. , Siggelkow, S. , Dengler, R. (2000). Alteration of sensorimotor integration in musician's cramp: Impaired focusing of proprioception.. Clinical Neurophysiology, 111, 2040– 2045 .Sadato, N. , Campbell, G. , Ibanez, V. , Deiber, M. , Hallett, M. (1996). Complexity affects regional cerebral blood flow change during sequential finger movements.. Journal of Neuroscience, 16, 2691– 2700 .Shibasaki, H. , Sadato, N. , Lyshkow, H. , Yonekura, Y. , Honda, M. , Nagamine, T. , et al. (1993). Both primary motor cortex and supplementary motor area play an important role in complex finger movement.. Brain, 116(Pt 6), 1387– 1398 .Steriade, M. , Llinas, R. (1988). The functional states of the thalamus and the associated neuronal interplay.. Physical Review, 68, 649– 742 .Tempel, L.W. , Perlmutter, J.S. (1993). Abnormal cortical responses in patients with writer's cramp.. Neurology, 43, 2252– 2257 .Tinazzi, M. , Zanette, G. (1998). Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities.. Neuroscience Letters, 244(3), 121– 124 .Todor, J.I. , Kyprie, P.M. , Price, H.L. (1982). Lateral asymmetries in arm, wrist and finger movements.. Cortex, 18(4), 515– 523 .Toro, C. , Deuschl, G. , Hallett, M. (2000). Movement-related electroencephalographic desynchronization in patients with hand cramps: Evidence for motor cortical involvement in focal dystonia.. Annals of Neurology, 47, 456– 461 .Toro, C. , Deuschl, G. , Thatcher, R. , Sato, S. , Kufta, C. , Hallett, M. (1994). Event-related desynchronization and movement-related cortical potentials on the ECoG and EEG.. Electroencephalography & Clinical Neurophysiology, 93, 380– 389 .Toyokura, M. , Muro, I. , Komiya, T. , Obara, M. (1999). Relation of bimanual coordination to activation in the sensorimotor cortex and supplementary motor area: Analysis using functional magnetic resonance imaging.. Brain Research Bulletin, 48, 211– 217 .Yazawa, S. , Shibasaki, H. , Ikeda, A. , Terada, K. , Nagamine, T. , Honda, M. (1997). Cortical mechanism underlying externally cued gait initiation studied by contingent negative variation.. Electromyography and Motor Control-Electroencephalography and Clinical Neurophysiology, 105, 390– 399 .
