Skip to main content
SpringerLink
Log in

Prediction of a Stable Microemulsion Formulation for the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

Purpose. The aim of this project was to develop a colloidal dosage form for the oral delivery of rifampicin and isoniazid in combination with the aid of artificial neural network (ANN) data modeling.

Methods. Data from the 20 pseudoternary phase triangles containing miglyol 812 as the oil component and a mixture of surfactants or a surfactant/cosurfactant blend were used to train, test, and validate the ANN model. The weight ratios of individual components were correlated with the observed phase behavior using radial basis function (RBF) network architecture. The criterion for judging the best model was the percentage success of the model prediction.

Results. The best model successfully predicted the microemulsion region as well as the coarse emulsion region but failed to predict the multiphase liquid crystalline phase for cosurfactant-free systems indicating the difference in microemulsion behavior on dilution with water.

Conclusions. A novel microemulsion formulation capable of delivering rifampicin and isoniazid in combination was created to allow for their differences in solubility and potential for chemical reaction. The developed model allowed better understanding of the process of microemulsion formation and stability within pseudoternary colloidal systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. World Health Organisation TB Report 1998, World Health Organisation Press Office, Geneva, 1998.

  2. South African Medicines Formulary (4th ed.). Department of Pharmacology, UCT, Pioneer Press, 1997, pp. 260-270.

  3. MIMS. Medical Specialities, Times Media. Pretoria 39:289-293 (1999).

  4. M. J. Lawrence. Microemulsions as drug delivery vehicles. Curr. Opin. Colloid Interface Sci. 1:826-832 (1996).

    Google Scholar 

  5. M. Malmsten. Microemulsions in pharmaceuticals. In P. Kumar, K. L. Mittal (eds.), Handbook of Microemulsion Science and Technology, Marcel Dekker, New York, 1999.

    Google Scholar 

  6. D. Attwood and G. Ktistis. A light scattering study on oil in water microemulsions. Int. J. Pharm. 52:165-171 (1989).

    Google Scholar 

  7. P. P. Constantinides and P. J. Scalart. Formulation and physical characterization of water in oil microemulsions containing long-versus medium-chain glycerides. Int. J. Pharm. 158:57-68 (1997).

    Google Scholar 

  8. J. Moody and C. J. Darkin. Fast learning in networks of locally-tuned processing units. Neural Comput. 1:281-294 (1989).

    Google Scholar 

  9. S. Haykin. Neural Networks: A Comprehensive Foundation. Macmillan, New York, 1994.

    Google Scholar 

  10. C. Bishop. Neural Networks for Pattern Recognition. Oxford University Press, Oxford, 1995.

    Google Scholar 

  11. M. Egmont-Petersen, J. L. Talmon, and A. Hasman. Assessing the importance of features for multi-layer perceptrons. Neural Networks 11:623-635 (1998).

    Google Scholar 

  12. G. Bologna, and C. Pellegrini. Three medical examples in neural network rule extraction. Phys. Med. 13:183-187 (1997).

    Google Scholar 

  13. T. F. Rathbun, S. K. Rogers, and M. P. DeSimio. MLP iterative construction algorithm. Neurocomputing 17:195-216 (1997).

    Google Scholar 

  14. J. Kreuter. Colloidal Drug Delivery Systems, Marcel Dekker, New York, 1994.

    Google Scholar 

  15. R. Aboofazelia, N. Patela, M. Thomasb, and M. J. Lawrencea. Investigations into the ormation and characterization of phospholipid microemulsions. IV. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol and oil; the influence of oil. Int. J. Pharm. 125:107-116 (1995).

    Google Scholar 

  16. M. Trotta, M. Gallarate, F. Pattarino, and M. E. Carlotti. Investigation of the phase behaviour of systems containing lecithin and 2-acyl lysolecithin derivatives. Int. J. Pharm. 190:83-89 (1999).

    Google Scholar 

  17. D. Attwood. Microemulsions. In H. Kreuter (ed.), Colloidal Drug Delivery Systems, Marcel Decker, New York, 1994, p. 31.

    Google Scholar 

  18. R. G. Alany, T. Rades, S. Agatonovic-Kustrin, N. G. Davies, and I. G. Tucker. Effect of alcohols and diols on the phase behaviour of quaternary systems. Int. J. Pharm. 196:141-145 (2000).

    Google Scholar 

  19. R. G. Alany, N. G. Davies, I. G. Tucker, and T. Rades. Characterising colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Dev. Ind. Pharmacy 27:31-38 (2001).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmaceutical, Molecular and Biomedical Science, University of South Australia, North Terrace, Adelaide, 5000, Australia

    Snezana Agatonovic-Kustrin

  2. School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland, 4811, Australia

    Beverley D. Glass

  3. Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa

    Michael H. Wisch

  4. Division of Pharmacy, The University of Auckland, Auckland, New Zealand

    Raid G. Alany

Authors
  1. Snezana Agatonovic-Kustrin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beverley D. Glass
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael H. Wisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Raid G. Alany
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Snezana Agatonovic-Kustrin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Agatonovic-Kustrin, S., Glass, B.D., Wisch, M.H. et al. Prediction of a Stable Microemulsion Formulation for the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology. Pharm Res 20, 1760–1765 (2003). https://doi.org/10.1023/B:PHAM.0000003372.56993.39

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:PHAM.0000003372.56993.39

Search

Navigation