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Proteinase Inhibitors from the Medicinal Leech Hirudo medicinalis

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Abstract

The medicinal leech Hirudo medicinalis produces various types of proteinase inhibitors: bdellins (inhibitors of trypsin, plasmin, and acrosin), hirustasin (inhibitor of tissue kallikrein, trypsin, α-chymotrypsin, and granulocyte cathepsin G), tryptase inhibitor, eglins (inhibitors of α-chymotrypsin, subtilisin, and chymasin and the granulocyte proteinases elastase and cathepsin G), inhibitor of factor Xa, hirudin (thrombin inhibitor), inhibitor of carboxypeptidase, and inhibitor of complement component C1s. This review summarizes data on their primary and tertiary structures, action mechanisms, and biological activities.

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  1. School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia

    I. P. Baskova

  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    L. L. Zavalova

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Baskova, I.P., Zavalova, L.L. Proteinase Inhibitors from the Medicinal Leech Hirudo medicinalis. Biochemistry (Moscow) 66, 703–714 (2001). https://doi.org/10.1023/A:1010223325313

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