REFERENCES
Baric I, Zschocke J, Christensen E, et al (1998) Diagnosis and management of glutaric aciduria type I. J Inher Metab Dis 21: 326–340.
Flott-Rahmel B, Falter C, Schluff R, et al (1997) Nerve cell lesions caused by 3OH-glutaric acid: a possible mechanism for neurodegeneration in glutaric acidaemia I? J Inher Metab Dis 20: 387–390.
Goodman SI, Norenberg MD, Shikes RH, Breslich DJ, Moe PG (1977) Glutaric aciduria: biochemical and morphological considerations. J Pediatr 90: 746–750.
Hoffmann GF, Trefz FK, Barth P, et al (1991) Glutaryl-CoA deficiency: a distinct encephalopathy. Pediatrics 88: 194–1203.
Hoffmann GF, Athanassopoulos S, Burlina AB, et al (1996) Clinical course, early diagnosis, treatment and prevention of disease in glutaryl-CoA dehydrogenase deficiency. Neuropediatrics 27: 115–123.
McDonald JW, Silverstein FS, Johnston MV (1988) Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system. Brain Res 459: 200–203.
McDonald JW, Behrens MI, Chung C, Bhattacharyya T, Choi DW (1997) Susceptibility to apoptosis is enhanced in immature cortical neurons. Brain Res 759: 228–232.
Merinero B, Pèrez-Cerdá C, Font LM, Garcia MJ, Aparicio M, Lorenzo G (1995) Variable clinical and biochemical presentation of seven Spanish cases with glutaryl-CoA dehydrogenase deficiency. Neuropediatrics 26: 238–242.
Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529–540.
Pettmann B, Louis JC, Sensenbrenner MCL (1979) Morphological and biochemical maturation of neurons cultured in the absence of glial cells. Nature 281: 378–380.
Portera-Cailliau C, Price DL, Martin LJ (1996) N-Methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies. J Neurochem 66: 692–700.
Priestley T, Ochu E, Kemp JA (1994) Subtypes of NMDA receptor in neuronal cultures from rat brain. Neuroreport 5: 1763–1765.
Wenzel A, Fritschy JM, Mohler H, Benke D (1997) NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem 68: 469–478.
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Kölker, S., Ahlemeyer, B., Krieglstein, J. et al. 3-Hydroxyglutaric and glutaric acids are neurotoxic through NMDA receptors in vitro. J Inherit Metab Dis 22, 259–262 (1999). https://doi.org/10.1023/A:1005577920954
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DOI: https://doi.org/10.1023/A:1005577920954