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The Tissue-Specific Methylation of Human-Specific Endogenous Retroviral LTRs

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Abstract

A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study.

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REFERENCES

  1. International Human Genome Sequencing Consortium, Nature, 2001, vol. 409, pp.860–921.

    Google Scholar 

  2. Di Cristofano, A., Strazullo, M., Longo, L., and La Mantia, G., Nucl. Acids Res., 1995, vol. 23, pp.2823–2830.

    PubMed  Google Scholar 

  3. Landry, J.R., Rouhi, A., Medstrand, P., and Mager, D.L., Mol. Biol. Evol., 2002, vol. 19, pp.1934–1942.

    PubMed  Google Scholar 

  4. Domansky, A.N., Kopantzev, E.P., Snezhkov, E.V., Lebedev, Y.B., Leib-Mosch, C., and Sverdlov, E.D., FEBS Lett., 2000, vol. 472, pp.191–195.

    PubMed  Google Scholar 

  5. Domansky, A.N., Akopov, S.B., Lebedev, Yu.B., Nikolaev, L.G., and Sverdlov, E.D., Bioorg. Khim., 2002, vol. 28, pp.341–345.

    PubMed  Google Scholar 

  6. Schon, U., Seifarth, W., Baust, C., Hohenadl, C., Erfle, V., and Leib-Mosch, C., Virology, 2001, vol. 279, pp. 280–291.

    PubMed  Google Scholar 

  7. Patzke, S., Lindeskog, M., Munthe, E., and Aasheim, H.C., Virology, 2002, vol. 303, pp.164–173.

    PubMed  Google Scholar 

  8. Ling, J., Pi, W., Bollag, R., Zeng, S., Keskintepe, M., Saliman, H., Krantz, S., Whitney, B., and Tuan, D., J. Virol., 2002, vol. 76, pp.2410–2423.

    PubMed  Google Scholar 

  9. Jaenisch, R. and Bird, A., Nat. Genet., 2003, vol. 33, pp. 245–254.

    PubMed  Google Scholar 

  10. Buzdin, A., Khodosevich, K., Mamedov, I., Vinogradova, T., Lebedev, Y., Hunsmann, G., and Sverdlov, E., Genomics, 2002, vol. 79, pp.413–422.

    PubMed  Google Scholar 

  11. Mamedov, I., Batrak, A., Buzdin, A., Arzumanyan, E., Lebedev, Y., and Sverdlov, E.D., Nucleic Acids Res., 2002, vol. 30, p. c71.

    Google Scholar 

  12. Buzdin, A.A., Lebedev, Yu.B., and Sverdlov, E.D., Bioorg. Khim., 2003, vol. 29, pp.103–106.

    PubMed  Google Scholar 

  13. Buzdin, A., Ustyugova, S., Khodosevich, K., Mamedov, I., Lebedev, Y., Hunsmann, G., and Sverdlov, E., Genomics, 2003, vol. 81, pp.149–156.

    PubMed  Google Scholar 

  14. Kidwell, M.G. and Lisch, D., Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp.7704–7711.

    PubMed  Google Scholar 

  15. Schuelke, M., Smeitink, J., Mariman, E., Loeffen, J., Plecko, B., Trijbels, F., Stockler-Ipsiroglu, S., and van den Heuvel, L., Nat. Genet., 1999, vol. 21, pp.260–261.

    PubMed  Google Scholar 

  16. Triepels, R., Smeitink, J., Loeffen, J., Smeets, R., Buskens, C., Trijbels, F., and van den Heuvel, L., J. Inherit. Metab. Dis., 1999, vol. 22, pp.163–173.

    PubMed  Google Scholar 

  17. de Coo, R.F., Buddiger, P.A., Smeets, H.J., and van Oost, B.A., Mamm. Genome, 1999, vol. 10, pp.49–53.

    PubMed  Google Scholar 

  18. Perez-Torres, S., Miro, X., Palacios, J.M., Cortes, R., Puigdomenech, P., and Mengod, G., J. Chem. Neuroanat., 2000, vol. 20, pp.349–374.

    PubMed  Google Scholar 

  19. D'Sa, C., Tolbert, L.M., Conti, M., and Duman, R.S., J. Neurochem., 2002, vol. 81, pp.745–757.

    PubMed  Google Scholar 

  20. Baroja, M.L., Cieslinski, L.B., Torphy, T.J., Wange, R.L., and Madrenas, J., J. Immunol., 1999, vol. 162, pp.2016–2023.

    PubMed  Google Scholar 

  21. Chu, W.-M., Ballard, R., Carpick, B.W., Williams, B.G., and Schmid, C.W., Mol. Cell. Biol., 1998, vol. 18, pp. 58–68.

    PubMed  Google Scholar 

  22. Sverdlov, E.D., Bioessays, 2000, vol. 22, pp.161–171.

    PubMed  Google Scholar 

  23. Sverdlov, E.D., FEBS Lett., 1998, vol. 428, pp.1–6.

    PubMed  Google Scholar 

  24. Khodosevich, K., Lebedev, Y., and Sverdlov, E., Comp. Funct. Genom., 2002, vol. 3, pp.494–498.

    Google Scholar 

  25. Sambrook, J. and Russell, D., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2001.

    Google Scholar 

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    K. V. Khodosevich, Yu. B. Lebedev & E. D. Sverdlov

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  1. K. V. Khodosevich
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  2. Yu. B. Lebedev
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  3. E. D. Sverdlov
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Khodosevich, K.V., Lebedev, Y.B. & Sverdlov, E.D. The Tissue-Specific Methylation of Human-Specific Endogenous Retroviral LTRs. Russian Journal of Bioorganic Chemistry 30, 441–445 (2004). https://doi.org/10.1023/B:RUBI.0000043787.07628.2a

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  • DOI: https://doi.org/10.1023/B:RUBI.0000043787.07628.2a

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