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Controlled Release of Farmazin from Thermosensitive Gels Based on Poly(N-vinylcaprolactam)

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Abstract

With the aim to prolong the effect of a wide-spectrum antimicrobial agent, Farmazin (tylosine tartrate), this drug was immobilized on a gel of N-vinylcaprolactam-sodium itaconate copolymer, which undergoes a phase transition on heating. The phase transition, accompanied by a change in volume, in aqueous solutions of the pure copolymer gel and that with the immobilized drug was studied.

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Authors and Affiliations

  1. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan

    R. M. Iskakov, S. V. Sedinkin, G. K. Mamytbekov, E. O. Batyrbekov, E. A. Bekturov & B. A. Zhubanov

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  1. R. M. Iskakov
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  2. S. V. Sedinkin
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  3. G. K. Mamytbekov
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  4. E. O. Batyrbekov
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  5. E. A. Bekturov
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  6. B. A. Zhubanov
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Iskakov, R.M., Sedinkin, S.V., Mamytbekov, G.K. et al. Controlled Release of Farmazin from Thermosensitive Gels Based on Poly(N-vinylcaprolactam). Russian Journal of Applied Chemistry 77, 339–341 (2004). https://doi.org/10.1023/B:RJAC.0000030380.07016.fa

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  • DOI: https://doi.org/10.1023/B:RJAC.0000030380.07016.fa

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